Department of Radiation Oncology.
Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee.
Int J Radiat Oncol Biol Phys. 2024 Jun 1;119(2):669-680. doi: 10.1016/j.ijrobp.2024.03.006.
The Pediatric Normal Tissue Effects in the Clinic (PENTEC) consortium has made significant contributions to understanding and mitigating the adverse effects of childhood cancer therapy. This review addresses the role of diagnostic imaging in detecting, screening, and comprehending radiation therapy-related late effects in children, drawing insights from individual organ-specific PENTEC reports. We further explore how the development of imaging biomarkers for key organ systems, alongside technical advancements and translational imaging approaches, may enhance the systematic application of imaging evaluations in childhood cancer survivors. Moreover, the review critically examines knowledge gaps and identifies technical and practical limitations of existing imaging modalities in the pediatric population. Addressing these challenges may expand access to, minimize the risk of, and optimize the real-world application of, new imaging techniques. The PENTEC team envisions this document as a roadmap for the future development of imaging strategies in childhood cancer survivors, with the overarching goal of improving long-term health outcomes and quality of life for this vulnerable population.
儿科正常组织器官在临床中的效应（PENTEC）联盟在理解和减轻儿童癌症治疗的不良反应方面做出了重大贡献。本综述探讨了诊断影像学在检测、筛查和理解儿童放射性治疗相关晚期效应中的作用，其依据源自于各个特定器官的 PENTEC 报告。我们进一步探讨了关键器官系统成像生物标志物的发展，以及技术进步和转化成像方法，如何增强在儿童癌症幸存者中系统应用影像学评估。此外，该综述还批判性地审视了现有成像方式在儿科人群中的知识空白和技术及实际局限性。解决这些挑战可能会扩大新成像技术的应用范围，降低其风险，并优化其在实际中的应用。PENTEC 团队将本文视为儿童癌症幸存者中影像学策略未来发展的路线图，其总体目标是改善这一脆弱人群的长期健康结果和生活质量。
