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肌动蛋白束集蛋白 SWAP-70 促进肿瘤转移。

The F-actin bundler SWAP-70 promotes tumor metastasis.

机构信息

https://ror.org/042aqky30 Institute for Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

https://ror.org/042aqky30 Cluster of Excellence Physics of Life, Technische Universität Dresden, Dresden, Germany.

出版信息

Life Sci Alliance. 2024 May 17;7(8). doi: 10.26508/lsa.202302307. Print 2024 Aug.

DOI:10.26508/lsa.202302307
PMID:38760173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11101836/
Abstract

Dynamic rearrangements of the F-actin cytoskeleton are a hallmark of tumor metastasis. Thus, proteins that govern F-actin rearrangements are of major interest for understanding metastasis and potential therapies. We hypothesized that the unique F-actin binding and bundling protein SWAP-70 contributes importantly to metastasis. Orthotopic, ectopic, and short-term tail vein injection mouse breast and lung cancer models revealed a strong positive dependence of lung and bone metastasis on SWAP-70. Breast cancer cell growth, migration, adhesion, and invasion assays revealed SWAP-70's key role in these metastasis-related cell features and the requirement for SWAP-70 to bind F-actin. Biophysical experiments showed that tumor cell stiffness and deformability are negatively modulated by SWAP-70. Together, we present a hitherto undescribed, unique F-actin modulator as an important contributor to tumor metastasis.

摘要

细胞骨架的动态重排是肿瘤转移的一个标志。因此，调控 F-actin 重排的蛋白质对于理解转移和潜在的治疗方法具有重要意义。我们假设独特的 F-actin 结合和束集蛋白 SWAP-70 对转移有重要贡献。在原位、异位和短期尾静脉注射的小鼠乳腺癌和肺癌模型中，SWAP-70 对肺和骨转移有很强的正依赖性。乳腺癌细胞生长、迁移、黏附和侵袭实验揭示了 SWAP-70 在这些与转移相关的细胞特征中的关键作用，以及 SWAP-70 结合 F-actin 的必要性。生物物理实验表明，肿瘤细胞的刚性和变形性被 SWAP-70 负调节。总之，我们提出了一个迄今为止尚未描述的独特的 F-actin 调节剂，作为肿瘤转移的一个重要贡献者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/d988aec85caa/LSA-2023-02307_Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/9f49ecac19cd/LSA-2023-02307_FigS1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/6d6f1d5335b9/LSA-2023-02307_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/4ec2b816d175/LSA-2023-02307_FigS2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/09f2f2071559/LSA-2023-02307_FigS3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/68296fc5e4ea/LSA-2023-02307_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/3e2f63f98885/LSA-2023-02307_FigS4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/a7a96a37df36/LSA-2023-02307_Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/3db0eb03cb71/LSA-2023-02307_FigS5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/e6f249cc6423/LSA-2023-02307_Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/fb087f87769e/LSA-2023-02307_FigS6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/d988aec85caa/LSA-2023-02307_Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/9f49ecac19cd/LSA-2023-02307_FigS1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/6d6f1d5335b9/LSA-2023-02307_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/4ec2b816d175/LSA-2023-02307_FigS2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/09f2f2071559/LSA-2023-02307_FigS3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/68296fc5e4ea/LSA-2023-02307_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/3e2f63f98885/LSA-2023-02307_FigS4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/a7a96a37df36/LSA-2023-02307_Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/3db0eb03cb71/LSA-2023-02307_FigS5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/e6f249cc6423/LSA-2023-02307_Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/fb087f87769e/LSA-2023-02307_FigS6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6662/11101836/d988aec85caa/LSA-2023-02307_Fig5.jpg

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