Nakajima H, Miyamoto H
Gan To Kagaku Ryoho. 1985 Sep;12(9):1735-43.
Diagnosis and therapy of malignant lymphoma of the skin were reviewed. Cutaneous T-cell lymphoma (CTCL), which is a new name for mycosis fungoides and Sezary syndrome, is one of the peripheral T-cell malignancies. It is generally confined to the skin for a long period of time, distinct from other malignant lymphomas, and may then progress to involve the lymph nodes and internal organs with a fatal outcome. Thus, diagnosis and therapy of CTCL may be different from those of other malignant lymphomas. Diagnostic characteristics of clinical, histopathological, haematological and immunological findings of CTCL were described. Differentiation between CTCL and adult T-cell leukemia-lymphoma (ATL) were discussed. As for the therapy for CTCL, there are five therapeutic modalities; local chemotherapy, PUVA therapy, electron beam irradiation therapy, systemic chemotherapy and combined modality. However, the most appropriate therapy for each stage of CTCL has not yet been determined. The advantages and dis-advantages of each therapeutical modality were discussed.
对皮肤恶性淋巴瘤的诊断与治疗进行了综述。皮肤T细胞淋巴瘤（CTCL）是蕈样肉芽肿和塞扎里综合征的新名称，是外周T细胞恶性肿瘤之一。它通常在很长一段时间内局限于皮肤，这与其他恶性淋巴瘤不同，随后可能进展累及淋巴结和内脏器官，导致致命后果。因此，CTCL的诊断和治疗可能与其他恶性淋巴瘤不同。描述了CTCL临床、组织病理学、血液学和免疫学检查结果的诊断特征。讨论了CTCL与成人T细胞白血病淋巴瘤（ATL）的鉴别。至于CTCL的治疗，有五种治疗方式：局部化疗、光化学疗法（PUVA）、电子束照射疗法、全身化疗和联合治疗。然而，尚未确定CTCL各阶段最合适的治疗方法。讨论了每种治疗方式的优缺点。
