Shanxi Medical University, Taiyuan, Shanxi, China.
Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
J Cell Mol Med. 2024 May;28(10):e18343. doi: 10.1111/jcmm.18343.
Fermented foods play a significant role in the human diet for their natural, highly nutritious and healthy attributes. Our aim was to study the effect of yeast extract, a fermented substance extracted from natural yeast, on colonic motility to better understand its potential therapeutic role. A yeast extract was given to rats by gavage for 3 days, and myogenic and neurogenic components of colonic motility were studied using spatiotemporal maps made from video recordings of the whole colon ex vivo. A control group received saline gavages. The yeast extract caused excitation of the musculature by increasing the propagation length and duration of long-distance contractions, the major propulsive activity of the rat colon. The yeast extract also evoked rhythmic propulsive motor complexes (RPMCs) which were antegrade in the proximal and mid-colon and retrograde in the distal colon. RPMC activity was evoked by distention-induced neural activity, but it was myogenic in nature since we showed it to be generated by bethanechol in the presence of tetrodotoxin. In conclusion, ingestion of yeast extract stimulates rat colon motility by exciting neurogenic and myogenic control mechanisms.
发酵食品因其天然、高营养和健康的特性，在人类饮食中占有重要地位。我们的目的是研究酵母提取物（一种从天然酵母中提取的发酵物质）对结肠运动的影响，以更好地了解其潜在的治疗作用。通过灌胃给大鼠酵母提取物 3 天，并使用离体全结肠的视频记录制作时空图谱来研究结肠运动的肌源性和神经源性成分。对照组给予生理盐水灌胃。酵母提取物通过增加长距离收缩的传播长度和持续时间来兴奋肌肉，长距离收缩是大鼠结肠的主要推进活动。酵母提取物还引起节律性推进运动复合波（RPMC），在近端和中段结肠呈顺行，在远端结肠呈逆行。RPMC 活动是由扩张诱导的神经活动引起的，但它是肌源性的，因为我们表明它是在四氢生物蝶呤存在下由氨甲酰胆碱产生的。总之，酵母提取物的摄入通过兴奋神经源性和肌源性控制机制刺激大鼠结肠运动。
