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MPTP的5-羟色胺能转化和MPP+的多巴胺能蓄积

Serotonergic conversion of MPTP and dopaminergic accumulation of MPP+.

作者信息

Shen R S, Abell C W, Gessner W, Brossi A

出版信息

FEBS Lett. 1985 Sep 23;189(2):225-30. doi: 10.1016/0014-5793(85)81028-0.

DOI:10.1016/0014-5793(85)81028-0
PMID:3876242
Abstract

[3H]MPP+ had lower Km and higher Vmax values for its accumulation in rat brain synaptosomes than did [3H]MPTP. The kinetic parameters favored the uptake of [3H]MPP+ in the striatum to that in hypothalamus, whereas they were equally favorable for the uptake of [3H]MPTP in both regions. Hypothalamic uptake of [3H]MPTP and [3H]MPP+ was inhibited by desipramine, imipramine, norepinephrine, and serotonin. Striatal uptake of [3H]MPP+ and [3H]MPTP was blocked by nomifensine and dopamine. These results support the concept that MPTP accumulates in serotonergic neurons where it is oxidized by monoamine oxidase B to MPP+, which is released and then is selectively accumulated in dopaminergic neurons via the dopamine uptake system.

摘要

与[3H]MPTP相比，[3H]MPP+在大鼠脑突触体中的积累具有更低的Km值和更高的Vmax值。动力学参数表明，[3H]MPP+在纹状体中的摄取优于下丘脑，而对于[3H]MPTP在这两个区域的摄取则同样有利。地昔帕明、丙咪嗪、去甲肾上腺素和5-羟色胺可抑制下丘脑对[3H]MPTP和[3H]MPP+的摄取。诺米芬辛和多巴胺可阻断纹状体对[3H]MPP+和[3H]MPTP的摄取。这些结果支持了以下概念：MPTP在5-羟色胺能神经元中积累，在那里它被单胺氧化酶B氧化为MPP+，MPP+被释放出来，然后通过多巴胺摄取系统选择性地积累在多巴胺能神经元中。

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Serotonergic conversion of MPTP and dopaminergic accumulation of MPP+.MPTP的5-羟色胺能转化和MPP+的多巴胺能蓄积
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Active uptake of MPP+, a metabolite of MPTP, by brain synaptosomes.脑突触体对MPTP的代谢产物MPP +的主动摄取。
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