Kinetics of [3H]MPP+ uptake in dopaminergic neurons of mouse: regional effects of MPTP neurotoxicity.
作者信息
Sershen H, Mason M F, Debler E A, Lajtha A
出版信息
Eur J Pharmacol. 1986 Jul 31;126(3):337-9. doi: 10.1016/0014-2999(86)90069-5.
PMID:3489627
Abstract
In an effort to determine the specificity of MPTP/MPP+ toxicity with respect to the dopaminergic systems, the effect of prior MPTP treatment on [3H]MPP+ uptake in the striatum and olfactory tubercle of BALB/cBy mice was examined. Kinetic analysis of [3H]MPP+ uptake indicated a reduction of Vmax values in both striatum (49%, P less than 0.05) and olfactory tubercule (26%, P less than 0.05). MPTP treatment did not significantly alter the Km in either region, although MPP+ accumulates in both olfactory tubercle and striatum, these dopaminergic systems show different sensitivity to the neurotoxicity of MPTP/MPP+.
摘要
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