Cytochemical studies on the secretory activity of guinea pig heterophils during sensitization.

Guinea pig males immunized with ovalbumin were investigated. Enzymes present in primary and secondary granules were revealed as well as sudanophilia and p.a.S.-positive substances, NBT test, phagocytosis and antigen binding capacity of blood heterophils. It is suggested that sorting out of enzymes and substances found in primary and secondary granules is related to decrease of cytoenzymatic reactions. Mechanisms of secretion of these substances during sensitization is discussed. The hypothesis about secretory and regulatory function of the heterophils is suggested.