Langhoff E, Ladefoged J
Int Arch Allergy Appl Immunol. 1985;78(2):218-20. doi: 10.1159/000233887.
In uremia, mitogen responses of lymphocytes are decreased as is their resistance to the immunosuppressive effect of steroids. We examined the functions of natural killer (NK) and killer (K) cells from uremic patients and their sensitivity to in vitro immunosuppression by methylprednisolone. NK- and K-cell activity was as high as that of control subjects, and remained so at different titrations of effector cells. The functions of NK and K cells from uremic patients tended to be more resistant to methylprednisolone than those of control NK and K cells. Thus, while uremia impairs T-cell functions and T-cell sensitivity to steroids in vitro, the cytotoxic effector cell functions which are not dependent on cell proliferation remain unaffected.
在尿毒症中，淋巴细胞的有丝分裂原反应降低，对类固醇免疫抑制作用的抵抗力也降低。我们检测了尿毒症患者自然杀伤（NK）细胞和杀伤（K）细胞的功能及其对甲基强的松龙体外免疫抑制的敏感性。NK细胞和K细胞活性与对照受试者一样高，并且在效应细胞的不同滴定度下保持如此。尿毒症患者的NK细胞和K细胞功能比对照NK细胞和K细胞功能对甲基强的松龙更具抵抗力。因此，虽然尿毒症在体外损害T细胞功能和T细胞对类固醇的敏感性，但不依赖于细胞增殖的细胞毒性效应细胞功能仍未受影响。
