Láng I, Taraba I, Petrányi G
Immunol Lett. 1981 Nov;3(5):267-71. doi: 10.1016/0165-2478(81)90003-1.
Antibody-dependent and spontaneous lymphocytotoxicity of blood mononuclear cells from 15 patients with chronic renal failure was studied in allogeneic K-562 and xenogeneic chicken erythrocyte test systems. Both antibody-dependent and spontaneous cytotoxic activities were significantly decreased in uremic patients as compared to the corresponding mean values of healthy control persons and non-uremic patients with the same underlying diseases. The addition of autologous serum further reduced the impaired cytotoxic capacity of uremic lymphocytes. Uremic sera also inhibited the antibody-dependent and spontaneous lymphocytotoxicity of healthy individuals.
在同种异体K-562和异种鸡红细胞检测系统中，研究了15例慢性肾衰竭患者血液单个核细胞的抗体依赖性和自发性淋巴细胞毒性。与健康对照者以及患有相同基础疾病的非尿毒症患者的相应平均值相比，尿毒症患者的抗体依赖性和自发性细胞毒性活性均显著降低。添加自体血清进一步降低了尿毒症淋巴细胞受损的细胞毒性能力。尿毒症血清也抑制健康个体的抗体依赖性和自发性淋巴细胞毒性。
