Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Department of Neurology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.
J Psychosom Res. 2024 Jul;182:111802. doi: 10.1016/j.jpsychores.2024.111802. Epub 2024 May 15.
The aim of this study was to assess the causal relationship between narcolepsy and anxiety using Mendelian randomization (MR) methodology.
Our research applied a bidirectional two-sample Mendelian Randomization strategy to explore the linkage between narcolepsy and anxiety. Utilizing summary data from GWAS on both conditions, we primarily employed the inverse-variance weighted technique for our analysis. To evaluate heterogeneity and horizontal pleiotropy, we utilized tools such as the MR Egger method, the weighted median method, Cochran's Q statistic, and the MR Egger intercept.
The analysis using the inverse variance-weighted method showed a clear positive link between narcolepsy and anxiety, with an odds ratio of 1.381 (95% CI: 1.161-1.642, p < 0.001). Tests for heterogeneity and horizontal pleiotropy, including MR Egger and IVW methods, indicated no significant findings (p-values 0.616 and 0.637, respectively, for heterogeneity; p = 0.463 for pleiotropy). Furthermore, no reverse causation was observed between anxiety and narcolepsy (odds ratio 1.034, 95% CI: 0.992-1.078, p = 0.111), with consistent findings across various analytical approaches.
This research suggests a possible causal link between narcolepsy and anxiety disorders. The results illuminate this connection and advocate additional studies to elucidate the mechanisms involved and to identify effective interventions.
本研究旨在应用孟德尔随机化（MR）方法评估嗜睡症与焦虑之间的因果关系。
本研究采用双向两样本 MR 策略，探索嗜睡症与焦虑之间的关联。利用两种疾病 GWAS 的汇总数据，我们主要采用逆方差加权法进行分析。为评估异质性和水平多效性，我们采用了 MR Egger 法、加权中位数法、Cochran's Q 统计量和 MR Egger 截距等工具。
采用逆方差加权法的分析表明，嗜睡症与焦虑之间存在明显的正相关关系，比值比为 1.381（95%CI：1.161-1.642，p<0.001）。异质性和水平多效性检验，包括 MR Egger 和 IVW 方法，均未发现显著结果（p 值分别为 0.616 和 0.637，用于异质性；p=0.463，用于多效性）。此外，焦虑与嗜睡症之间未观察到反向因果关系（比值比 1.034，95%CI：0.992-1.078，p=0.111），各种分析方法均得出一致的结果。
本研究提示嗜睡症与焦虑障碍之间可能存在因果关系。结果提示了这种联系，并倡导开展更多研究以阐明相关机制，并确定有效的干预措施。
