肠外鱼油对早产儿神经发育的影响：叙述性综述。
The effects of parenteral fish oil on neurodevelopment in preterm infants: A narrative review.
机构信息
Women and Kids Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.
Women and Kids Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2024 Feb;201:102620. doi: 10.1016/j.plefa.2024.102620. Epub 2024 May 15.
OBJECTIVE
This narrative review aimed to summarize studies assessing the effects of parenteral fish oil on neurodevelopment in preterm infants.
METHODS
PubMed was searched (July 1985 to October 2023). We reviewed randomized controlled trials, and observational studies assessing intravenous lipid emulsion with fish oil in preterm infants (born less than 37 weeks' gestation), that reported long-term neurodevelopmental outcomes.
RESULTS
We identified four publications relating to three randomized controlled trials in addition to four cohort studies. Study designs and outcomes were heterogenous and precluded meta-analyses. Results of trials were null for a selection of neurodevelopmental outcomes, however possible benefits of parenteral fish oil supplementation for neurodevelopment was reported in three cohort studies. Certainty of the evidence is hindered by methodological limitations of available trials and observational studies.
CONCLUSIONS
Further research is required to firmly establish the effects of parenteral fish oil on preterm neurodevelopment.
目的
本综述旨在总结评估静脉用鱼油对早产儿神经发育影响的研究。
方法
检索 PubMed（1985 年 7 月至 2023 年 10 月）。我们综述了评估静脉用脂肪乳剂中添加鱼油对早产儿（胎龄小于 37 周）的随机对照试验和观察性研究，这些研究报告了长期神经发育结局。
结果
我们确定了四篇与三项随机对照试验相关的文献，此外还有四项队列研究。研究设计和结果存在异质性，因此无法进行荟萃分析。尽管部分试验的神经发育结局为阴性，但三项队列研究报告了静脉用鱼油补充可能对神经发育有益。由于现有试验和观察性研究存在方法学局限性，证据的确定性受到影响。
结论
需要进一步研究以明确静脉用鱼油对早产儿神经发育的影响。
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