Hirsch R L, Ordonez J, Panitch H S, Johnson K P
J Neuroimmunol. 1985 Oct;9(6):391-8. doi: 10.1016/s0165-5728(85)80038-2.
Fluorescence-activated cell sorter (FACS) analysis was used to quantitate the antigen density of the lymphocyte markers T3, T4, T8, and Leu 7 on the surface of peripheral blood mononuclear cells (MNC) from exacerbating/remitting multiple sclerosis (MS) patients. Serial studies showed that the mean fluoresce intensity for all the markers studied did not change significantly during exacerbations. There was a tendency for a generalized decline in T-cells, evidenced by a drop in both T8+- and T4+-cells; however, these changes were not statistically significant. It appears, therefore, that the lymphocyte markers studied here are not useful as markers of disease activity in exacerbating/remitting MS.
采用荧光激活细胞分选仪（FACS）分析技术，对复发缓解型多发性硬化症（MS）患者外周血单个核细胞（MNC）表面淋巴细胞标志物T3、T4、T8和Leu 7的抗原密度进行定量分析。系列研究表明，在病情加重期间，所有研究标志物的平均荧光强度均无显著变化。T8 +细胞和T4 +细胞数量均下降，提示T细胞有普遍减少的趋势；然而，这些变化无统计学意义。因此，本文所研究的淋巴细胞标志物似乎无助于作为复发缓解型MS疾病活动的标志物。
