Suci Yulia Devina, Permatasari Ariani, Koesomoprodjo Winariani
Department of Pulmonology and Respiratory Medicine, Dr Soetomo Academic Hospital, Airlangga University Faculty of Medicine, Surabaya, Indonesia.
Respir Med Case Rep. 2024 Apr 30;50:102030. doi: 10.1016/j.rmcr.2024.102030. eCollection 2024.
Extrapulmonary tuberculosis could affect many organs beside lung airway and parenchyma. The mycobacterium tuberculosis can invade area such as the pleural and pericardium by lymphogenic, hematogenic, or direct infection. Patient with history exposure with silica (SiO2) have a high-risk factor developing tuberculosis or extrapulmonary tuberculosis. Therefore, this study presents a rare case of pulmonary silicosis in a 38 years-old-man with tuberculosis pericarditis and pleuritis. The amount of silica particle found in bronchoalveolar lavage (BAL) was 39,95 ppm SiO2, while the ADA test from the pericardium and pleural fluids was 35.4 U/L and 40.2 U/L, respectively. The patient underwent pericardiocentesis and thoracocentesis, received first-line anti-tuberculosis drugs, and resigned from work. After one month follow-up, the pericardial as well as pleural fluid totally disappeared. This disease can mimic any other disease. Early detection of risk factor for extrapulmonary tuberculosis and perform the right diagnostic and treatment will give a better outcome for the patient.
肺外结核可累及肺气道和实质以外的许多器官。结核分枝杆菌可通过淋巴源性、血源性或直接感染侵犯胸膜和心包等部位。有二氧化硅(SiO₂)接触史的患者发生结核病或肺外结核的风险较高。因此,本研究报告了一例38岁男性患肺结核合并心包炎和胸膜炎的罕见病例。支气管肺泡灌洗(BAL)中发现的二氧化硅颗粒量为39.95 ppm SiO₂,而心包液和胸腔积液的ADA检测值分别为35.4 U/L和40.2 U/L。该患者接受了心包穿刺和胸腔穿刺,接受了一线抗结核药物治疗,并辞职。经过一个月的随访,心包液和胸腔积液完全消失。这种疾病可类似任何其他疾病。早期发现肺外结核的危险因素并进行正确的诊断和治疗将为患者带来更好的预后。