Kou Xian-Shuai, Li Fan-Fan, Meng Yun, Zhao Jian-Ming, Liu Sheng-Fen, Zhang Lan
The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China.
Department of Thoracic Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
World J Gastrointest Oncol. 2024 May 15;16(5):2225-2232. doi: 10.4251/wjgo.v16.i5.2225.
Hepatocellular carcinoma (HCC), a major contributor to cancer-related deaths, is particularly prevalent in Asia, largely due to hepatitis B virus infection. Its prognosis is generally poor. This case report contributes to the medical literature by detailing a unique approach in treating a large HCC through multidisciplinary collaboration, particularly in patients with massive HCC complicated by ruptured bleeding, a scenario not extensively documented previously.
The patient presented with large HCC complicated by intratumoral bleeding. Treatment involved a multidisciplinary approach, providing individualized care. The strategy included drug-eluting bead transarterial chemoembolization, sorafenib-targeted therapy, laparoscopic partial hepatectomy, and standardized sintilimab monoclonal antibody therapy. Six months after treatment, the patient achieved complete radiological remission, with significant symptom relief. Imaging studies showed no lesions or recurrence, and clinical assessments confirmed complete remission. This report is notable as possibly the first documented case of successfully treating such complex HCC conditions through integrated multidisciplinary efforts, offering new insights and a reference for future similar cases.
This study demonstrated effective multidisciplinary treatment for massive HCC with intratumoral bleeding, providing insights for future similar cases.
肝细胞癌（HCC）是癌症相关死亡的主要原因之一，在亚洲尤为普遍，主要归因于乙型肝炎病毒感染。其预后通常较差。本病例报告通过详细阐述一种多学科协作治疗大型HCC的独特方法，为医学文献做出了贡献，特别是对于伴有破裂出血的巨大HCC患者，这一情况此前未被广泛记录。
该患者患有大型HCC并伴有瘤内出血。治疗采用多学科方法，提供个性化护理。治疗策略包括载药微球经动脉化疗栓塞、索拉非尼靶向治疗、腹腔镜部分肝切除术以及标准化的信迪利单抗单克隆抗体治疗。治疗六个月后，患者实现了影像学完全缓解，症状明显缓解。影像学检查未发现病变或复发，临床评估证实完全缓解。本报告值得注意，因为它可能是首例通过综合多学科努力成功治疗此类复杂HCC病例的记录，为未来类似病例提供了新的见解和参考。
本研究证明了对伴有瘤内出血的巨大HCC进行多学科治疗的有效性，为未来类似病例提供了见解。
