Zuo Qian, Wu Yingchao, Hu Yuyu, Shao Cui, Liang Yuqi, Chen Liushan, Guo Qianqian, Huang Ping, Chen Qianjun
State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Department of Breast, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
Heliyon. 2024 May 7;10(9):e30807. doi: 10.1016/j.heliyon.2024.e30807. eCollection 2024 May 15.
In the last ten years, there has been a notable rise in the study of metabolic abnormalities in cancer cells. However, compared to glucose or glutamine metabolism, less attention has been paid to the importance of lipid metabolism in tumorigenesis. Recent developments in lipidomics technologies have allowed for detailed analysis of lipid profiles within cancer cells and other cellular players present within the tumor microenvironment (TME). Traditional Chinese medicine (TCM) and its bioactive components have a long history of use in cancer treatments and are also being studied for their potential role in regulating metabolic reprogramming within TME. This review focuses on four core abnormalities altered by lipid reprogramming in cancer cells: de novo synthesis and exogenous uptake of fatty acids (FAs), upregulated fatty acid oxidation (FAO), cholesterol accumulation, which offer benefits for tumor growth and metastasis. The review also discusses how altered lipid metabolism impacts infiltrating immune cell function and phenotype as these interactions between cancer-stromal become more pronounced during tumor progression. Finally, recent literature is highlighted regarding how cancer cells can be metabolically reprogrammed by specific Chinese herbal components with potential therapeutic benefits related to lipid metabolic and signaling pathways.
在过去十年中，癌细胞代谢异常的研究显著增加。然而，与葡萄糖或谷氨酰胺代谢相比，脂质代谢在肿瘤发生中的重要性受到的关注较少。脂质组学技术的最新进展使得对癌细胞内以及肿瘤微环境（TME）中其他细胞成分的脂质谱进行详细分析成为可能。中药及其生物活性成分在癌症治疗中的应用历史悠久，目前也正在研究它们在调节TME内代谢重编程方面的潜在作用。本综述重点关注癌细胞中脂质重编程改变的四个核心异常：脂肪酸（FAs）的从头合成和外源性摄取、脂肪酸氧化（FAO）上调、胆固醇积累，这些异常为肿瘤生长和转移提供了有利条件。综述还讨论了脂质代谢改变如何影响浸润免疫细胞的功能和表型，因为在肿瘤进展过程中，癌症-基质之间的这些相互作用变得更加明显。最后，强调了最近的文献，即癌细胞如何通过特定的中药成分进行代谢重编程，这些成分在脂质代谢和信号通路方面具有潜在的治疗益处。
