Gupte Hospital & Center for Research in Reproduction Department of Obstetrics and Gynecology India Department of Obstetrics and Gynecology, Gupte Hospital & Center for Research in Reproduction, India.
CSS College of Obstetrics Gynae. & Child health Department of Gynecology Kolkata India Department of Gynecology, CSS College of Obstetrics, Gynae. & Child health, Kolkata, India.
Rev Bras Ginecol Obstet. 2024 Mar 15;46. doi: 10.61622/rbgo/2024AO21. eCollection 2024.
OBJECTIVE: We conducted a meta-analysis of randomized clinical trials evaluating the clinical effects of ferric carboxymaltose therapy compared to other intravenous iron in improving hemoglobin and serum ferritin in pregnant women. We also assessed the safety of ferric carboxymaltose vs. other intravenous iron. DATA SOURCE: EMBASE, PubMed, and Web of Science were searched for trials related to ferric carboxymaltose in pregnant women, published between 2005 and 2021. We also reviewed articles from google scholar. The keywords "ferric carboxymaltose," "FCM," "intravenous," "randomized," "pregnancy," "quality of life," and "neonatal outcomes" were used to search the literature. The search was limited to pregnant women. SELECTION OF STUDIES: Studies related to ferric carboxymaltose in pregnancy were scanned. Observational studies, review articles, and case reports were excluded. Randomized studies in pregnant women involving ferric carboxymaltose and other intravenous iron formulations were shortlisted. Of 256 studies, nine randomized control trials were selected. DATA COLLECTION: Two reviewers independently extracted data from nine selected trials. DATA SYNTHESIS: The final effect size for increase in hemoglobin after treatment was significant for ferric carboxymaltose vs. iron sucrose/iron polymaltose (standard mean difference 0.89g/dl [95% confidence interval 0.27,1.51]). The final effect size for the increase in ferritin after treatment was more for ferric carboxymaltose vs. iron sucrose/iron polymaltose (standard mean difference 22.53µg/L [-7.26, 52.33]). No serious adverse events were reported with ferric carboxymaltose or other intravenous iron. CONCLUSION: Ferric carboxymaltose demonstrated better efficacy than other intravenous iron in increasing hemoglobin and ferritin levels in treating iron deficiency anemia in pregnant women.
目的:我们对评估羧基麦芽糖铁治疗与其他静脉铁剂治疗改善孕妇血红蛋白和血清铁蛋白的临床效果的随机临床试验进行了荟萃分析。我们还评估了羧基麦芽糖铁与其他静脉铁剂相比的安全性。
资料来源:我们检索了 2005 年至 2021 年间与羧基麦芽糖铁在孕妇中相关的临床试验,检索数据库包括 EMBASE、PubMed 和 Web of Science。我们还查阅了谷歌学术上的文章。使用“ferric carboxymaltose”、“FCM”、“intravenous”、“randomized”、“pregnancy”、“quality of life”和“neonatal outcomes”等关键词搜索文献。检索范围仅限于孕妇。
研究选择:扫描与妊娠中铁羧基麦芽糖铁相关的研究。排除了观察性研究、综述文章和病例报告。筛选出了涉及羧基麦芽糖铁和其他静脉铁制剂的孕妇随机研究。在 256 项研究中,有 9 项随机对照试验入选。
资料收集:两位评审员独立从 9 项入选试验中提取资料。
资料综合:治疗后血红蛋白增加的最终效应大小对于羧基麦芽糖铁与蔗糖铁/铁多聚麦芽糖(标准均数差 0.89g/dl [95%置信区间 0.27,1.51])具有显著意义。治疗后铁蛋白增加的最终效应大小对于羧基麦芽糖铁与蔗糖铁/铁多聚麦芽糖(标准均数差 22.53µg/L [-7.26, 52.33])更为显著。羧基麦芽糖铁或其他静脉铁均未报告严重不良事件。
结论:羧基麦芽糖铁在治疗孕妇缺铁性贫血方面,在提高血红蛋白和铁蛋白水平方面的疗效优于其他静脉铁剂。
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