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一项关于羧基麦芽糖铁与其他静脉用铁剂治疗妊娠期缺铁性贫血的荟萃分析。

A meta-analysis of ferric carboxymaltose versus other intravenous iron preparations for the management of iron deficiency anemia during pregnancy.

机构信息

Gupte Hospital & Center for Research in Reproduction Department of Obstetrics and Gynecology India Department of Obstetrics and Gynecology, Gupte Hospital & Center for Research in Reproduction, India.

CSS College of Obstetrics Gynae. & Child health Department of Gynecology Kolkata India Department of Gynecology, CSS College of Obstetrics, Gynae. & Child health, Kolkata, India.

出版信息

Rev Bras Ginecol Obstet. 2024 Mar 15;46. doi: 10.61622/rbgo/2024AO21. eCollection 2024.


DOI:10.61622/rbgo/2024AO21
PMID:38765534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11075392/
Abstract

OBJECTIVE: We conducted a meta-analysis of randomized clinical trials evaluating the clinical effects of ferric carboxymaltose therapy compared to other intravenous iron in improving hemoglobin and serum ferritin in pregnant women. We also assessed the safety of ferric carboxymaltose vs. other intravenous iron. DATA SOURCE: EMBASE, PubMed, and Web of Science were searched for trials related to ferric carboxymaltose in pregnant women, published between 2005 and 2021. We also reviewed articles from google scholar. The keywords "ferric carboxymaltose," "FCM," "intravenous," "randomized," "pregnancy," "quality of life," and "neonatal outcomes" were used to search the literature. The search was limited to pregnant women. SELECTION OF STUDIES: Studies related to ferric carboxymaltose in pregnancy were scanned. Observational studies, review articles, and case reports were excluded. Randomized studies in pregnant women involving ferric carboxymaltose and other intravenous iron formulations were shortlisted. Of 256 studies, nine randomized control trials were selected. DATA COLLECTION: Two reviewers independently extracted data from nine selected trials. DATA SYNTHESIS: The final effect size for increase in hemoglobin after treatment was significant for ferric carboxymaltose vs. iron sucrose/iron polymaltose (standard mean difference 0.89g/dl [95% confidence interval 0.27,1.51]). The final effect size for the increase in ferritin after treatment was more for ferric carboxymaltose vs. iron sucrose/iron polymaltose (standard mean difference 22.53µg/L [-7.26, 52.33]). No serious adverse events were reported with ferric carboxymaltose or other intravenous iron. CONCLUSION: Ferric carboxymaltose demonstrated better efficacy than other intravenous iron in increasing hemoglobin and ferritin levels in treating iron deficiency anemia in pregnant women.

摘要

目的:我们对评估羧基麦芽糖铁治疗与其他静脉铁剂治疗改善孕妇血红蛋白和血清铁蛋白的临床效果的随机临床试验进行了荟萃分析。我们还评估了羧基麦芽糖铁与其他静脉铁剂相比的安全性。

资料来源:我们检索了 2005 年至 2021 年间与羧基麦芽糖铁在孕妇中相关的临床试验,检索数据库包括 EMBASE、PubMed 和 Web of Science。我们还查阅了谷歌学术上的文章。使用“ferric carboxymaltose”、“FCM”、“intravenous”、“randomized”、“pregnancy”、“quality of life”和“neonatal outcomes”等关键词搜索文献。检索范围仅限于孕妇。

研究选择:扫描与妊娠中铁羧基麦芽糖铁相关的研究。排除了观察性研究、综述文章和病例报告。筛选出了涉及羧基麦芽糖铁和其他静脉铁制剂的孕妇随机研究。在 256 项研究中,有 9 项随机对照试验入选。

资料收集:两位评审员独立从 9 项入选试验中提取资料。

资料综合:治疗后血红蛋白增加的最终效应大小对于羧基麦芽糖铁与蔗糖铁/铁多聚麦芽糖(标准均数差 0.89g/dl [95%置信区间 0.27,1.51])具有显著意义。治疗后铁蛋白增加的最终效应大小对于羧基麦芽糖铁与蔗糖铁/铁多聚麦芽糖(标准均数差 22.53µg/L [-7.26, 52.33])更为显著。羧基麦芽糖铁或其他静脉铁均未报告严重不良事件。

结论:羧基麦芽糖铁在治疗孕妇缺铁性贫血方面,在提高血红蛋白和铁蛋白水平方面的疗效优于其他静脉铁剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/d7d176f8c745/1806-9339-rbgo-46-e-rbgo21-gf08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/08a02f60a4b3/1806-9339-rbgo-46-e-rbgo21-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/2780c8fbef1e/1806-9339-rbgo-46-e-rbgo21-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/bc9af3d1d98d/1806-9339-rbgo-46-e-rbgo21-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/a91a6067b51e/1806-9339-rbgo-46-e-rbgo21-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/f35d1ee8ed62/1806-9339-rbgo-46-e-rbgo21-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/97d04bf59e1f/1806-9339-rbgo-46-e-rbgo21-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/00bad74c3ac9/1806-9339-rbgo-46-e-rbgo21-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/d7d176f8c745/1806-9339-rbgo-46-e-rbgo21-gf08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/08a02f60a4b3/1806-9339-rbgo-46-e-rbgo21-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/2780c8fbef1e/1806-9339-rbgo-46-e-rbgo21-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/bc9af3d1d98d/1806-9339-rbgo-46-e-rbgo21-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/a91a6067b51e/1806-9339-rbgo-46-e-rbgo21-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/f35d1ee8ed62/1806-9339-rbgo-46-e-rbgo21-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/97d04bf59e1f/1806-9339-rbgo-46-e-rbgo21-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/00bad74c3ac9/1806-9339-rbgo-46-e-rbgo21-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5369/11075392/d7d176f8c745/1806-9339-rbgo-46-e-rbgo21-gf08.jpg

相似文献

[1]
A meta-analysis of ferric carboxymaltose versus other intravenous iron preparations for the management of iron deficiency anemia during pregnancy.

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[6]
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[9]
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[10]
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引用本文的文献

[1]
Iron dysregulation, ferroptosis, and oxidative stress in diabetic osteoporosis: Mechanisms, bone metabolism disruption, and therapeutic strategies.

World J Diabetes. 2025-6-15

[2]
Safety and Efficacy of Ferric Carboxymaltose for Iron Deficiency Anemia in Inflammatory Bowel Disease: A Systematic Review.

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[3]
Hypersensitive reaction due to ferric carboxymaltose in a post-partum mother experienced in a tertiary care hospital in West Bengal, India: A case report.

SAGE Open Med Case Rep. 2024-10-18

本文引用的文献

[1]
The impact of response to iron therapy on maternal and neonatal outcomes among pregnant women with anemia.

Am J Obstet Gynecol MFM. 2022-3

[2]
Anemia in Pregnancy: Screening and Clinical Management Strategies.

MCN Am J Matern Child Nurs.

[3]
Comparative efficacy and safety of intravenous ferric carboxymaltose and iron sucrose for iron deficiency anemia in obstetric and gynecologic patients: A systematic review and meta-analysis.

Medicine (Baltimore). 2021-5-21

[4]
Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial.

Lancet. 2020-11-13

[5]
Prevalence of anemia and iron deficiency anemia in Chinese pregnant women (IRON WOMEN): a national cross-sectional survey.

BMC Pregnancy Childbirth. 2020-11-7

[6]
Iron Deficiency Anemia in Pregnancy: Novel Approaches for an Old Problem.

Oman Med J. 2020-9-1

[7]
Comparison of ferric Carboxymaltose and iron sucrose complex for treatment of iron deficiency anemia in pregnancy- randomised controlled trial.

BMC Pregnancy Childbirth. 2019-2-4

[8]
A Prospective Randomised Controlled Trial of a Single Intravenous Infusion of Ferric Carboxymaltose vs Single Intravenous Iron Polymaltose or Daily Oral Ferrous Sulphate in the Treatment of Iron Deficiency Anaemia in Pregnancy.

Semin Hematol. 2018-4-25

[9]
Management of Iron Deficiency Anemia in Pregnancy in India.

Indian J Hematol Blood Transfus. 2018-4

[10]
Ferric Carboxymaltose: A Review in Iron Deficiency.

Drugs. 2018-3

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