Lavie Peretz
Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Sleep Adv. 2024 May 17;5(1):zpae027. doi: 10.1093/sleepadvances/zpae027. eCollection 2024.
In this paper, I describe my 45-year career in sleep research. I started my undergraduate studies at Tel Aviv University, where I was first introduced to the enchanted world of sleep, continued to my graduate studies with Wilse B. Webb at the University of Florida, and then to post-doctoral training with Dan Kripke at the University of California at San Diego. Then, I describe the evolution of my academic career at the Technion-Israel Institute of Technology, where I started in 1975 as an Assistant Professor and retired in 2019 as the President of the Institute. I describe the areas of research that I pursued and how the research developed, emphasizing unexpected results that guided me and my lab team in new directions. This includes my early studies on ultradian rhythms, inspired by Nathaniel Kleitman's Basic Rest Activity Cyle hypothesis, utilizing the ultrashort sleep-wake paradigm to chart the 24-hour sleep propensity function, and how these studies led us to explore the role of melatonin in sleep regulation. I also explain why we directed our attention to sleep apnea, and how clinical observations led to the provocative hypothesis that sleep apnea-typically seen as a disorder-may also play a protective role. Under the leadership of my research partner and wife, Lena, we confirmed this hypothesis. Also in this article, I describe my enthusiasm for the history of our field and, as derived from my experience as a Dean of Medicine and President of a university, I share my philosophy about the role of members of academia in society. I emphasize that none of my achievements could have been accomplished without the hard work and motivation of my students and research partners, who shared my enthusiasm and passion for the enchanted world of sleep. This paper is part of the Living Legends in Sleep Research series, which is sponsored by Idorsia Pharmaceuticals and Jazz Pharmaceuticals.
在本文中，我将讲述自己45年的睡眠研究职业生涯。我在特拉维夫大学开始本科学习，在那里我首次踏入了迷人的睡眠世界，之后在佛罗里达大学跟随威尔西·B·韦布继续攻读研究生，然后在加利福尼亚大学圣地亚哥分校跟随丹·克里普克进行博士后培训。接着，我描述了自己在以色列理工学院的学术生涯发展历程，我于1975年以助理教授身份开始任职，2019年以该学院院长身份退休。我阐述了自己所从事的研究领域以及研究是如何发展的，着重强调那些引导我和我的实验室团队转向新方向的意外结果。这包括我早期受纳撒尼尔·克莱特曼的基本休息活动周期假说启发而对超日节律进行的研究，利用超短睡眠 - 清醒范式绘制24小时睡眠倾向函数，以及这些研究如何引导我们探索褪黑素在睡眠调节中的作用。我还解释了我们为何将注意力转向睡眠呼吸暂停，以及临床观察如何引发了一个具有启发性的假说，即通常被视为一种疾病的睡眠呼吸暂停可能也起到保护作用。在我的研究伙伴兼妻子莉娜的领导下，我们证实了这一假说。同样在本文中，我描述了自己对我们这个领域历史的热情，并且基于我担任医学院院长和大学校长的经历，分享了我对学术界成员在社会中所扮演角色的理念。我强调，如果没有我的学生和研究伙伴的辛勤工作与动力，我不可能取得任何成就，他们与我一样对迷人的睡眠世界充满热情。本文是由艾多西亚制药公司和爵士制药公司赞助的“睡眠研究领域传奇人物”系列文章的一部分。
