Wu Yating, Wang Xiao, Wang Xiaoye, He Zhenyu, Wang Rui, Chen Zhihan, Wu Xiaomin
Institution of Food and Environmental Hygiene, Wuhan Center for Disease Control and Prevention, Wuhan, China.
Public Health Emergency Center, Chinese Center for Disease Control and Prevention, Beijing, China.
Front Nutr. 2024 May 3;11:1333888. doi: 10.3389/fnut.2024.1333888. eCollection 2024.
To analyze the epidemiological characteristics and etiology of crayfish-related rhabdomyolysis.
Cases of crayfish-related rhabdomyolysis in Wuhan were monitored, and professional training of city's surveillance personnel was conducted. Unified questionnaires were used to collect data.
The first case of crayfish-related rhabdomyolysis occurred on July 12, 2016. Subsequently, 423 patients were reported over the next 7 years, with muscle pain, weakness, and chest distress as main symptoms. In total, 64.54% (273/423) of patients were females, and young adults (aged 20-49 years) account for 86.22% (363/423) of patients. The primary clinical presentations were muscle pain, muscle weakness, and chest discomfort. The median incubation time was 6 h. And the number of cases may be related to water levels in Yangzi river. Laboratory tests revealed elevated creatine kinase and myoglobin levels. In total, 95.16% (236/248) of patients had consumed crayfish tail shrimp and 91.53% (227/248) had consumed crayfish liver and pancreas (Female crayfish also contain ovaries). Only 25.00% (62/248) of patients had a history of alcohol consumption. On average, 227 patients consumed 15 (3-50) crayfish, of whom 84.14% (191/227) consumed more than 10 crayfish. All patients had a favorable prognosis.
Crayfish-related rhabdomyolysis is a kind of a case or cluster of patients present with severe myalgia or weakness of unknown etiology and mechanism disease in Wuhan, China, 2016-2022. Excessive consumption of crayfish may be a risk factor for the disease. The relationship between the specific parts of crayfish consumed and the onset of the disease is unclear, suggesting further research is needed to identify the relevant risk factors for the disease.
分析小龙虾相关横纹肌溶解症的流行病学特征及病因。
对武汉地区小龙虾相关横纹肌溶解症病例进行监测，并对全市监测人员进行专业培训。采用统一问卷收集数据。
首例小龙虾相关横纹肌溶解症于2016年7月12日出现。随后，在接下来的7年里共报告了423例患者，主要症状为肌肉疼痛、无力和胸部不适。患者中女性占64.54%（273/423），青壮年（20 - 49岁）占86.22%（363/423）。主要临床表现为肌肉疼痛、肌肉无力和胸部不适。中位潜伏期为6小时。病例数可能与长江水位有关。实验室检查显示肌酸激酶和肌红蛋白水平升高。95.16%（236/248）的患者食用过小龙虾尾虾，91.53%（227/248）的患者食用过小龙虾肝胰（雌虾还含有卵巢）。仅有25.00%（62/248）的患者有饮酒史。平均227名患者食用了15只（3 - 50只）小龙虾，其中84.14%（191/227）的患者食用超过10只小龙虾。所有患者预后良好。
小龙虾相关横纹肌溶解症是2016 - 2022年在中国武汉出现的一种病因和发病机制不明的以严重肌痛或肌无力为表现的散发病例或聚集性病例。过量食用小龙虾可能是该病的一个危险因素。食用小龙虾的特定部位与发病之间的关系尚不清楚，提示需要进一步研究以确定该病的相关危险因素。
