一名原发性淀粉样变性和肾病综合征患者获得性因子X和抗凝血酶III缺乏症。
Acquired factor X and antithrombin III deficiency in a patient with primary amyloidosis and nephrotic syndrome.
作者信息
Quitt M, Aghai E, David M, Kohan R, Ben Ari Y, Froom P
出版信息
Scand J Haematol. 1985 Aug;35(2):155-7. doi: 10.1111/j.1600-0609.1985.tb01564.x.
A 45-year-old man with primary amyloidosis was initially seen with nephrotic syndrome. Factor X was found to be 5% and antithrombin III (AT III) 45% of normal plasma values. During an 11-month period, despite severe factor X deficiency, the patient did not have any bleeding complications. He developed progressive renal failure and AT III levels increased to normal, at which time he developed severe bleeding complications. These findings suggest a protective role of AT III deficiency against bleeding in a patient with severe factor X deficiency.
一名45岁的原发性淀粉样变性男性患者最初因肾病综合征就诊。发现其因子X水平为正常血浆值的5%，抗凝血酶III（AT III）为45%。在11个月的时间里，尽管因子X严重缺乏，但该患者并未出现任何出血并发症。他出现了进行性肾衰竭，同时AT III水平升至正常，此时他出现了严重的出血并发症。这些发现提示，在严重因子X缺乏的患者中，AT III缺乏对出血具有保护作用。
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