Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, China.
Department of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Leuk Lymphoma. 2024 Sep;65(9):1303-1313. doi: 10.1080/10428194.2024.2350665. Epub 2024 May 20.
The present study aimed to investigate the real-world results of childhood acute lymphoblastic leukemia (cALL) cases in Fujian, China. The clinical data of 1414 patients with newly diagnosed cALL in Fujian were retrospectively analyzed. Patients were treated according to the Chinese Children Leukemia Group 2008 protocol (CCLG-ALL 2008 group) or Chinese Children's Cancer Group 2015 protocol (CCCG-ALL 2015 group). Cumulative incidence of treatment abandonment (TA) at 5 years was 4.2% ± 0.6% and significantly associated with treatment period and risk stratification. The 5-OS and EFS were significantly higher in the CCCG-ALL 2015 group than in the CCLG-ALL 2008 group. Patients treated with CCCG-ALL 2015 from Fujian Medical Union Hospital had a significantly higher 4-year OS and EFS than did those from the other four hospitals. Real-world TA of cALL greatly decreased, and its long-term survival significantly increased in Fujian, which may be related to optimizing programs, multi-center collaboration, and improving treatment compliance.
本研究旨在探讨中国福建儿童急性淋巴细胞白血病（cALL）的真实世界结果。回顾性分析了福建 1414 例新诊断为 cALL 的患者的临床资料。患者根据中国儿童白血病协作组 2008 方案（CCLG-ALL 2008 组）或中国儿童癌症协作组 2015 方案（CCCG-ALL 2015 组）进行治疗。5 年治疗中断（TA）累积发生率为 4.2%±0.6%，且与治疗期和危险分层显著相关。CCCG-ALL 2015 组的 5 年总生存率（OS）和无事件生存率（EFS）显著高于 CCLG-ALL 2008 组。来自福建医科大学附属协和医院的 CCCG-ALL 2015 治疗组患者的 4 年 OS 和 EFS 显著高于其他四家医院。福建儿童 cALL 的真实世界 TA 大大降低，长期生存率显著提高，这可能与方案优化、多中心合作和提高治疗依从性有关。
