Institute of Ophthalmology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Indian J Ophthalmol. 2024 Aug 1;72(8):1147-1149. doi: 10.4103/IJO.IJO_2697_23. Epub 2024 May 20.
To assess the safety and efficacy of transzonular moxifloxacin and dexamethasone versus standard postoperative topical drug regimen in phacoemulsification.
Nonrandomized prospective study.
The study included 100 eyes of 100 age and gender-matched individuals with senile cataract undergoing routine phacoemulsification. The patients were consecutively divided into transzonular (TZ = 50) and topical (TP = 50) groups. Both the groups were followed up for 4 weeks and assessed for intraocular inflammation, visual acuity, changes in intraocular pressure (IOP), and any adverse events.
The grades of inflammation were significantly lower in TZ as compared to the TP group ( P < 0.001). The IOP remained normal and comparable in both the groups. Most of the patients in the two groups attained a visual acuity of 0.2 or better at the end of the follow-up. No adverse effects and increased rate of endophthalmitis were noted in TZ group.
A one-time peroperative TZ moxifloxacin and dexamethasone combination is a safe and effective method to control postoperative inflammation after cataract surgery. A word of caution though, due precautions to be exercised to prevent the risk of inflammation and endophthalmitis.
评估经巩膜莫西沙星和地塞米松与白内障超声乳化术后标准局部药物治疗方案的安全性和有效性。
非随机前瞻性研究。
本研究纳入了 100 例年龄和性别匹配的老年性白内障患者的 100 只眼，均行常规超声乳化白内障吸除术。患者连续分为经巩膜（TZ=50）和局部（TP=50）两组。两组均随访 4 周，评估眼内炎症、视力、眼压（IOP）变化及任何不良事件。
TZ 组的炎症分级明显低于 TP 组（P<0.001）。两组的 IOP 均保持正常且相似。两组患者在随访结束时大多达到 0.2 或更好的视力。TZ 组未出现不良反应和眼内炎发生率增加。
白内障术后单次经巩膜莫西沙星和地塞米松联合应用是控制术后炎症的一种安全有效的方法。但需注意，应谨慎操作以预防炎症和眼内炎的风险。
