Gungor Sirel Gur, Bulam Begum, Akman Ahmet, Colak Meric
Department of Ophthalmology, Faculty of Medicine, Başkent University, Ankara, Turkey.
Indian J Ophthalmol. 2014 Aug;62(8):861-4. doi: 10.4103/0301-4738.141045.
To compare the results of intracameral dexamethasone and intracameral triamcinolone acetonide injection in patients that underwent cataract surgery with phacoemulsification.
Sixty eyes of 60 patients that underwent cataract surgery with phacoemulsification were randomized into two groups. Preoperative visual acuity of all patients was 0.5 or lower and intraocular pressures were under 21mmHg. After surgery, eyes in group 1 (30 eyes) were injected with 0.4 mg/0.1 ml dexamethasone into the anterior chamber, and eyes in group 2 (30 eyes) were injected with 2 mg/0.05 ml triamcinolone acetonide into the anterior chamber. All eyes received standard postoperative prednisolone acetate and moxifloxacin eye drops. The biomicroscopic evaluation, visual acuity, and intraocular pressure measurements were done at baseline (preoperatively) and on postoperative days 1, 7 and 30.
There were no statistically significant differences in mean visual acuity, the amount of anterior cells and flare between the two groups (P ≥ 0.05). Mean intraocular pressure values at postoperative first day were significantly higher in group 2 than in group 1 (P = 0.009). The mean intraocular pressures on days 7 and 30 after surgery were not statistically different between the two groups (P ≥ 0.05).
Intracameral dexamethasone and intracameral triamcinolone acetonide were similarly effective in controlling postoperative inflammation following phacoemulsification. However, the intraocular pressures on postoperative first day were higher in patients receiving intracameral triamcinolone acetonide. The highest intraocular pressure in triamcinolone acetonide group was 24 mmHg, and stabilized in a few days, therefore using triamcinolone acetonide may impose a minimal risk to patients. Nevertheless, intracameral dexamethasone seems to be a better alternative to apply at the end of surgery to suppress the inflammation during the first 24 hours.
比较白内障超声乳化手术患者前房注射地塞米松与前房注射曲安奈德的效果。
60例行白内障超声乳化手术的患者的60只眼被随机分为两组。所有患者术前视力均为0.5或更低，眼压低于21mmHg。术后，第1组（30只眼）的眼睛前房注射0.4mg/0.1ml地塞米松，第2组（30只眼）的眼睛前房注射2mg/0.05ml曲安奈德。所有眼睛均接受标准的术后醋酸泼尼松龙和莫西沙星滴眼液治疗。在基线（术前）以及术后第1天、第7天和第30天进行生物显微镜评估、视力和眼压测量。
两组之间的平均视力、前房细胞数量和闪光量无统计学显著差异（P≥0.05）。术后第1天第2组的平均眼压值显著高于第1组（P = 0.009）。术后第7天和第30天两组之间的平均眼压无统计学差异（P≥0.05）。
前房注射地塞米松和前房注射曲安奈德在控制超声乳化术后炎症方面效果相似。然而，接受前房注射曲安奈德的患者术后第1天的眼压较高。曲安奈德组的最高眼压为24mmHg，并在数天内稳定下来，因此使用曲安奈德对患者造成的风险可能最小。尽管如此，前房注射地塞米松似乎是在手术结束时应用以抑制最初24小时内炎症的更好选择。
