Department of Blood Transfusion, The Central Hospital of Shaoyang, Shaoyang, China.
Changchun Bioxun Biotechnology Limited Liability Company, 285 Xinpu Road, Changchun, Jilin, China.
Int J Hematol. 2024 Jul;120(1):44-49. doi: 10.1007/s12185-024-03791-3. Epub 2024 May 20.
Augustine is a newly identified blood group system comprising four antigens, one of which is the high-frequency antigen At in the original "series". Four antigens are located on a multipass membrane glycoprotein equilibrative nucleoside transporter 1 (ENT1), and equilibrative nucleoside transporter is encoded by SLC29A1. In 2016, the International Society of Blood Transfusion (ISBT) recognised Augustine as a blood group system and numbered it as 036. The glycoprotein ENT1 transports nucleotides into cells to participate in the synthesis of DNA and RNA, and this is an important link for chemotherapeutic glycosides to enter tumour cells. Augustine antibodies are clinically relevant in blood transfusion and pregnancy.
奥古斯丁是一个新发现的血型系统，包含四个抗原，其中一个是原始“系列”中的高频抗原 At。这四个抗原位于多通道膜糖蛋白平衡核苷转运蛋白 1（ENT1）上，平衡核苷转运蛋白由 SLC29A1 编码。2016 年，国际输血协会（ISBT）将奥古斯丁确认为一个血型系统，并将其编号为 036。糖蛋白 ENT1 将核苷酸转运到细胞内参与 DNA 和 RNA 的合成，这是化疗糖苷进入肿瘤细胞的重要环节。奥古斯丁抗体在输血和妊娠中具有临床意义。
