Wang Wenjie, Zheng Peijia, Yan Liang, Chen Xiaoman, Wang Zhicheng, Liu Qi
Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
School of Stomatology, Southern Medical University, Guangzhou, China.
Free Radic Res. 2024 May;58(5):333-353. doi: 10.1080/10715762.2024.2358026. Epub 2024 May 24.
Non-thermal atmospheric plasma (NTAP) has been proven to be an effective anti-tumor tool, with various biological effects such as inhibiting tumor proliferation, metastasis, and promoting tumor cell apoptosis. At present, the main conclusion is that ROS and RNS are the main effector components of NTAP, but the mechanisms of which still lack systematic summary. Therefore, in this review, we first summarized the mechanism by which NTAP directly or indirectly causes an increase in intracellular RONS concentration, and the multiple pathways dysregulation (i.e. NRF2, PI3K, MAPK, NF-κB) induced by intracellular RONS. Then, we generalized the relationship between NTAP induced pathways dysregulation and the various biological effects it brought. The summary of the anti-tumor mechanism of NTAP is helpful for its further research and clinical transformation.
非热大气等离子体（NTAP）已被证明是一种有效的抗肿瘤工具，具有抑制肿瘤增殖、转移以及促进肿瘤细胞凋亡等多种生物学效应。目前，主要结论是活性氧（ROS）和活性氮（RNS）是NTAP的主要效应成分，但其机制仍缺乏系统总结。因此，在本综述中，我们首先总结了NTAP直接或间接导致细胞内活性氧氮物种（RONS）浓度升高的机制，以及细胞内RONS诱导的多种信号通路失调（即核因子E2相关因子2（NRF2）、磷脂酰肌醇-3激酶（PI3K）、丝裂原活化蛋白激酶（MAPK）、核因子κB（NF-κB））。然后，我们归纳了NTAP诱导的信号通路失调与其所带来的各种生物学效应之间的关系。NTAP抗肿瘤机制的总结有助于其进一步研究和临床转化。
