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先天性心脏病管理的变革:胎儿心脏介入治疗的进展。

Transforming congenital heart disease management: Advances in fetal cardiac interventions.

机构信息

Division of Maternal-Fetal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.

出版信息

Prenat Diagn. 2024 Jun;44(6-7):733-738. doi: 10.1002/pd.6592. Epub 2024 May 20.

DOI:10.1002/pd.6592
PMID:38768017
Abstract

This review addresses the transformative advancements in fetal cardiac interventions (FCI) for congenital heart diseases (CHD), with a particular focus on aortic stenosis with evolving hypoplastic left heart syndrome, pulmonary atresia with an intact ventricular septum, and HLHS with an intact atrial septum (HLHS-IAS). We outline the specific FCI techniques employed, the refined criteria for selecting appropriate fetal and maternal candidates, and the promising yet varied outcomes associated with these procedures. Procedural strategies and clinical decision-making are examined as we take into account the fetal pathophysiology and the benefits and risks of early intervention. We highlight the role of multidisciplinary teams in improving technical success and managing immediate procedural complications, which have led to significant improvements in procedural outcomes. Additionally, the review discusses the long-term outcomes, challenges, and future research directions in FCI, emphasizing the necessity for continuous innovation and collaboration across specialties to advance the management of CHD. The integration of new technologies and research findings holds the promise of further enhancing FCI success rates and patient outcomes.

摘要

这篇综述探讨了胎儿心脏介入治疗(FCI)在先天性心脏病(CHD)方面的变革性进展,特别关注主动脉瓣狭窄伴左心发育不良综合征、肺动脉瓣闭锁伴完整室间隔和房间隔完整的 HLHS(HLHS-IAS)。我们概述了所采用的特定 FCI 技术、选择合适胎儿和母体候选者的细化标准,以及与这些手术相关的有前途但各不相同的结果。我们在考虑胎儿病理生理学以及早期干预的益处和风险的同时,检查了手术策略和临床决策。我们强调了多学科团队在提高技术成功率和处理即时手术并发症方面的作用,这些并发症导致了手术结果的显著改善。此外,该综述还讨论了 FCI 的长期结果、挑战和未来研究方向,强调了在各专业领域不断创新和合作以推进 CHD 管理的必要性。新技术和研究结果的整合有望进一步提高 FCI 的成功率和患者的结果。

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Transforming congenital heart disease management: Advances in fetal cardiac interventions.先天性心脏病管理的变革:胎儿心脏介入治疗的进展。
Prenat Diagn. 2024 Jun;44(6-7):733-738. doi: 10.1002/pd.6592. Epub 2024 May 20.
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The boundaries of fetal cardiac intervention: Expand or tighten?胎儿心脏介入治疗的边界:扩大还是收紧?
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Fetal interventions for congenital heart disease.先天性心脏病的胎儿干预措施。
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Fetal cardiac interventions: Where do we stand?胎儿心脏介入治疗:我们处于什么位置?
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Navigating women with congenital heart disease during pregnancy: Management strategies and future directions.孕期先天性心脏病女性的管理:策略与未来方向
World J Cardiol. 2025 Jun 26;17(6):106295. doi: 10.4330/wjc.v17.i6.106295.
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The molecular mechanisms of cardiac development and related diseases.心脏发育及相关疾病的分子机制。
Signal Transduct Target Ther. 2024 Dec 23;9(1):368. doi: 10.1038/s41392-024-02069-8.