University of Alabama at Birmingham, Department of Neurology, 1719 6(th) Ave S, Birmingham, AL 35233, United States.
University of Alabama at Birmingham, Department of Neurology, 1719 6(th) Ave S, Birmingham, AL 35233, United States.
Brain Res. 2024 Sep 15;1839:149016. doi: 10.1016/j.brainres.2024.149016. Epub 2024 May 18.
There is a critical need for neuroimaging markers of brain integrity to monitor effects of modifiable lifestyle factors on brain health. This observational, cross-sectional study assessed relationships between brain microstructure and sleep, physical fitness, and cognition in healthy older adults.
Twenty-three adults aged 60 and older underwent whole-brain multi-shell diffusion imaging, comprehensive cognitive testing, polysomnography, and exercise testing. Neurite Orientation Dispersion and Density Imaging (NODDI) was used to quantify neurite density (NDI) and orientation dispersion (ODI). Diffusion tensor imaging (DTI) was used to quantify axial diffusivity (AxD), fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD). Relationships between sleep efficiency (SE), time and percent in N3 sleep, cognitive function, physical fitness (VO peak) and the diffusion metrics in regions of interest and the whole brain were evaluated.
Higher NDI in bilateral white and gray matter was associated with better executive functioning. NDI in the right anterior cingulate and adjacent white matter was positively associated with language skills. Higher NDI in the left posterior corona radiata was associated with faster processing speed. Physical fitness was positively associated with NDI in the left precentral gyrus and corticospinal tract. N3 % was positively associated with NDI in the left caudate and right pre- and postcentral gyri. Higher ODI in the left putamen and adjacent white matter was associated with better executive function.
NDI and ODI derived from NODDI are potential neuroimaging markers for associations between brain microstructure and modifiable risk factors in aging. If these associations are observable in clinical samples, NODDI could be incorporated into clinical trials assessing the effects of modifiable risk factors on brain integrity in aging and neurodegenerative diseases.
目前急需神经影像学标志物来监测可改变的生活方式因素对大脑健康的影响。本观察性、横断面研究评估了健康老年人的大脑微观结构与睡眠、身体健康和认知之间的关系。
23 名年龄在 60 岁及以上的成年人接受了全脑多壳扩散成像、全面认知测试、多导睡眠图和运动测试。使用神经丝取向分散和密度成像（NODDI）来量化神经丝密度（NDI）和取向分散（ODI）。弥散张量成像（DTI）用于量化轴向弥散度（AxD）、分数各向异性（FA）、平均弥散度（MD）和径向弥散度（RD）。评估了睡眠效率（SE）、N3 睡眠时间、认知功能、身体健康（VO 峰值）与感兴趣区和整个大脑的扩散指标之间的关系。
双侧白质和灰质中的 NDI 越高，执行功能越好。右侧前扣带及其相邻白质中的 NDI 与语言技能呈正相关。左后冠状辐射中的 NDI 越高，处理速度越快。身体健康与左中央前回和皮质脊髓束中的 NDI 呈正相关。N3%与左尾状核和右中央前、后回中的 NDI 呈正相关。左侧壳核和相邻白质中的 ODI 越高，执行功能越好。
来自 NODDI 的 NDI 和 ODI 是大脑微观结构与衰老过程中可改变风险因素之间关联的潜在神经影像学标志物。如果这些关联在临床样本中可观察到，那么 NODDI 可以纳入评估可改变风险因素对衰老和神经退行性疾病中大脑完整性影响的临床试验中。
Zotero 插件