睾丸脂肪含量的量化：隐睾症手术后评估睾丸功能的价值。

Quantification of testicular fat content: the value of evaluating testicular function after cryptorchidism surgery.

作者信息

Li Qingling, Zhang Jie, Li Quanxi, Zhong Shuangshuang, Zhou Xiang, Zou Fengyun, Deng Yayin, Luo Xiaowen, Shen Lishan, Chen Xi, Guo Ruomi

机构信息

Department of Radiology, the Third Affiliated Hospital, Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, PR China.

Department of VIP Medical Center, the Third Affiliated Hospital, Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, PR China.

出版信息

Pediatr Res. 2024 Dec;96(7):1788-1793. doi: 10.1038/s41390-024-03272-7. Epub 2024 May 20.

DOI:10.1038/s41390-024-03272-7

PMID:38769403

Abstract

BACKGROUND

To investigate the correlation between testicular fat content (TFC) and sex hormone levels in patients with cryptorchidism and its value in assessing postsurgical testicular function.

METHODS

Pelvic MRI with the mDIXON Quant sequence was performed on 23 cryptorchidism patients and 15 normal controls. The TFC before and after surgery was measured and compared. The correlations between cryptorchid TFC and testosterone (TSTO), follicle-stimulating hormone (FSH), and estradiol (E2) levels were analyzed, as was the specificity of TFC and each hormone for assessing testicular function after surgery.

RESULTS

The preoperative cryptorchid TFC (3.06% ± 0.74) was higher than that of the normal controls (1.36% ± 0.49). TSTO was negatively correlated with the cryptorchid TFC (r = -0.698), while FSH and E2 were positively associated with the cryptorchid TFC (r = 0.658, 0.676). Cryptorchid TFC after surgery (2.01% ± 0.55) was lower than the preoperative TFC, but hormone levels were not significantly different. The TFC after surgery (0.864) had a larger AUC value than did TSTO (0.639), FSH (0.597), and E2 (0.586).

CONCLUSION

Noninvasive quantification of cryptorchid TFC using the mDIXON Quant sequence is more specific than hormone levels for assessing postsurgical changes in testicular function.

IMPACT

The cryptorchid testicular fat content is significantly higher than the normal testicular fat content. Cryptorchid testicular fat content is negatively correlated with presurgical serum TSTO levels and positively correlated with presurgical FSH and E2 levels. Pre- and postoperative changes in cryptorchid testicular fat content change are more sensitive than changes in TSTO, FSH, or E2 levels. Noninvasive cryptorchid testicular fat content quantified by the mDIXON Quant sequence is more specific than serum TSTO, FSH, and E2 levels for assessing changes in testicular function after cryptorchidism surgery.

摘要

背景

探讨隐睾症患者睾丸脂肪含量（TFC）与性激素水平之间的相关性及其在评估术后睾丸功能中的价值。

方法

对23例隐睾症患者和15例正常对照者进行采用mDIXON Quant序列的盆腔MRI检查。测量并比较手术前后的TFC。分析隐睾TFC与睾酮（TSTO）、促卵泡激素（FSH）和雌二醇（E2）水平之间的相关性，以及TFC和每种激素在评估术后睾丸功能方面的特异性。

结果

术前隐睾TFC（3.06%±0.74）高于正常对照者（1.36%±0.49）。TSTO与隐睾TFC呈负相关（r = -0.698），而FSH和E2与隐睾TFC呈正相关（r = 0.658，0.676）。术后隐睾TFC（2.01%±0.55）低于术前TFC，但激素水平无显著差异。术后TFC的AUC值（0.864）大于TSTO（0.639）、FSH（0.597）和E2（0.586）。

结论

使用mDIXON Quant序列对隐睾TFC进行无创定量在评估术后睾丸功能变化方面比激素水平更具特异性。

影响

隐睾睾丸脂肪含量显著高于正常睾丸脂肪含量。隐睾睾丸脂肪含量与术前血清TSTO水平呈负相关，与术前FSH和E2水平呈正相关。隐睾睾丸脂肪含量术前和术后的变化比TSTO、FSH或E2水平的变化更敏感。通过mDIXON Quant序列无创定量的隐睾睾丸脂肪含量在评估隐睾症手术后睾丸功能变化方面比血清TSTO、FSH和E2水平更具特异性。