Killoran Sarah, McNamara Sinéad, Kavanagh Pierce, O'Brien John, Lakes Rodney
Forensic Science Ireland, Dublin, Ireland.
HSE National Drug Treatment Centre Laboratory, Dublin, Ireland.
Drug Test Anal. 2025 Mar;17(3):350-357. doi: 10.1002/dta.3707. Epub 2024 May 20.
Synthetic opioids have been associated globally with adverse effects in drug users. The nitazene group of drugs is a relatively new addition to the synthetic opioid class emerging in Europe in 2019. Some nitazenes have been shown to be more potent than fentanyl. Overdose clusters in heroin users in Dublin (57 cases) and Cork (20 cases), Ireland, in November and December 2023, respectively, prompted a rapid response from a number of Irish laboratories to identify the substance(s) of concern. Light brown (tan) powders were obtained from cases associated with overdoses, and the results from these analyses by collaboration of four laboratories are reported here. The samples were found to contain N-pyrrolidino protonitazene (protonitazepyne), caffeine, paracetamol, benzoic acid and mannitol.
合成阿片类药物在全球范围内与吸毒者的不良反应有关。硝氮烯类药物是合成阿片类药物中的一个相对新的类别，于2019年在欧洲出现。一些硝氮烯已被证明比芬太尼更有效。2023年11月和12月，爱尔兰都柏林（57例）和科克（20例）分别出现海洛因使用者过量用药聚集事件，促使爱尔兰多个实验室迅速做出反应，以确定相关物质。从与过量用药相关的病例中获取了浅棕色（棕褐色）粉末，这里报告了四个实验室合作进行这些分析的结果。样本中发现含有N-吡咯烷基硝氮烯（硝氮烯炔）、咖啡因、对乙酰氨基酚、苯甲酸和甘露醇。
