Szewczuk M R, Wade A W
Gerontology. 1985;31(4):251-62. doi: 10.1159/000212708.
In the present study, we examined the changes that occur with age in anti-idiotype-blocked, hapten-augmentable PFC in the mucosal-associated lymph nodes (MLN and BLN) and spleen of various strains of mice. 2-month-old 129/J, AKR/J, and C57L/J mice had a high percentage of hapten-augmentable PFC in their spleen, MLN, and BLN; however, by 6-11 months these values had declined considerably in the spleen, while mucosal values remained high. In contrast, 2-month-old C57BL/6J, DBA/2J, and C3H/HeJ mice had a low percentage of hapten-augmentable PFC in their spleen, MLN, and BLN; but by 6-11 months these values had increased considerably in the spleen, while mucosal values remained low. CBA/J and SJL/J mice maintained high and low levels, respectively, of hapten-augmentable PFC in their spleens, MLN, and BLN over the age span. NZB/BinJ mice were found to be low producers in the spleen, but high in the MLN and BLN at 2 and 6 months of age. These data indicate that there are strain differences in the development of auto-anti-idiotypic antibody regulation with age.
在本研究中，我们检测了不同品系小鼠的黏膜相关淋巴结（肠系膜淋巴结和支气管旁淋巴结）及脾脏中，抗独特型封闭、半抗原增强的空斑形成细胞（PFC）随年龄增长所发生的变化。2月龄的129/J、AKR/J和C57L/J小鼠在其脾脏、肠系膜淋巴结和支气管旁淋巴结中有高比例的半抗原增强PFC；然而，到6 - 11月龄时，这些数值在脾脏中显著下降，而黏膜相关淋巴结中的数值仍保持较高水平。相比之下，2月龄的C57BL/6J、DBA/2J和C3H/HeJ小鼠在其脾脏、肠系膜淋巴结和支气管旁淋巴结中的半抗原增强PFC比例较低；但到6 - 11月龄时，这些数值在脾脏中显著增加，而黏膜相关淋巴结中的数值仍保持较低水平。在整个年龄跨度内，CBA/J和SJL/J小鼠在其脾脏、肠系膜淋巴结和支气管旁淋巴结中分别维持着半抗原增强PFC的高水平和低水平。发现NZB/BinJ小鼠在脾脏中产生PFC的能力较低，但在2月龄和6月龄时，在肠系膜淋巴结和支气管旁淋巴结中产生PFC的能力较高。这些数据表明，自身抗独特型抗体调节的发育随年龄增长存在品系差异。
