The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
J Cutan Pathol. 2024 Sep;51(9):658-661. doi: 10.1111/cup.14659. Epub 2024 May 20.
Cytophagic histiocytic panniculitis (CHP) is associated with a number of systemic conditions and is characterized by the presence of benign phagocytic histiocytes ("bean bag cells"), including phagocytosed erythrocytes, leukocytes, and platelets. We describe a case of a 72-year-old female who presented with a papular eruption that clinically mimicked pityriasis lichenoides et varioliformis acuta (PLEVA). Given that her skin biopsy had multiple features concerning PLEVA, this diagnosis was classified as a superficial pityriasis lichenoides-like variant of CHP. The histopathologic presence of cytophagic histiocytosis prompted workup for a systemic malignancy, leading to a diagnosis of underlying acute monocytic leukemia of myeloid lineage.
噬血细胞性组织细胞增生症（CHP）与许多系统性疾病相关，其特征为存在良性吞噬性组织细胞（“豆袋细胞”），包括吞噬的红细胞、白细胞和血小板。我们描述了一例 72 岁女性患者，其表现为丘疹性发疹，临床表现类似于急性痘疮样苔藓样糠疹样变体（PLEVA）。鉴于她的皮肤活检具有多个与 PLEVA 相关的特征，因此将该诊断归类为浅表性 PLEVA 样 CHP 变体。噬血细胞性组织细胞的组织病理学存在促使对系统性恶性肿瘤进行检查，从而诊断为潜在的急性单核细胞白血病。
