Zhang Qianqian, Zhang Lei, Lin Guoqiang, Luo Fanyan
Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Heliyon. 2024 May 9;10(10):e30952. doi: 10.1016/j.heliyon.2024.e30952. eCollection 2024 May 30.
Ischemia-reperfusion injury (IRI) encompasses the damage resulting from the restoration of blood supply following tissue ischemia. This phenomenon commonly occurs in clinical scenarios such as hemorrhagic shock, severe trauma, organ transplantation, and thrombolytic therapy. Despite its prevalence, existing treatments exhibit limited efficacy against IRI. Vagus nerve stimulation (VNS) is a widely utilized technique for modulating the autonomic nervous system. Numerous studies have demonstrated that VNS significantly reduces IRI in various organs, including the heart, brain, and liver. This article reviews the pathological processes during IRI and summarizes the role and possible mechanisms of VNS in IRI of different organs. Furthermore, this review addresses the current challenges of VNS clinical applications, providing a novel perspective on IRI treatment.
缺血再灌注损伤（IRI）包括组织缺血后恢复血液供应所导致的损伤。这种现象常见于诸如失血性休克、严重创伤、器官移植和溶栓治疗等临床情况。尽管其普遍存在，但现有的治疗方法对IRI的疗效有限。迷走神经刺激（VNS）是一种广泛用于调节自主神经系统的技术。大量研究表明，VNS能显著减轻包括心脏、大脑和肝脏在内的各种器官的IRI。本文综述了IRI期间的病理过程，总结了VNS在不同器官IRI中的作用及可能机制。此外，本综述还探讨了VNS临床应用当前面临的挑战，为IRI治疗提供了新的视角。
