Staubach Petra, Körber Andreas, Trüeb Ralph M, Mann Caroline, von Kiedrowski Ralph
Department of Dermatology and Allergy, University Medical Center, Mainz, Germany.
Private Practice, Hautärzte Rue 143, 45130 Essen, Germany.
Drugs Context. 2024 May 15;13. doi: 10.7573/dic.2024-1-6. eCollection 2024.
The scalp is the most common site affected in patients with psoriasis with up to 80% of these patients having some degree of scalp involvement. In this narrative review, we evaluate available data on the use of an innovative aerosol foam formulation of calcipotriol plus betamethasone dipropionate (Cal/BD) to treat patients with psoriasis and scalp involvement. The full PubMed database was searched using the terms "calcipotriol", "betamethasone dipropionate" and "aerosol foam", and all articles relating to "psoriasis with scalp involvement" were retrieved and used in the preparation of this review. The evidence supporting the clinical effectiveness, tolerability and impact on health outcomes of Cal/BD aerosol foam in patients with scalp psoriasis was obtained from a phase II clinical trial and real-world evidence data from a non-interventional study as well as from two case series. The findings from these studies show that Cal/BD aerosol foam is rapidly effective, improves skin condition, alleviates symptoms such as itch, and has a positive impact on patient quality of life. These attributes address several unmet needs for patients with psoriasis with scalp involvement and have the potential to improve individual adherence to treatment.
头皮是银屑病患者最常受累的部位，高达80%的此类患者有一定程度的头皮受累。在这篇叙述性综述中，我们评估了关于使用创新型卡泊三醇加二丙酸倍他米松气雾剂泡沫制剂（Cal/BD）治疗头皮受累银屑病患者的现有数据。使用关键词“卡泊三醇”“二丙酸倍他米松”和“气雾剂泡沫”检索了完整的PubMed数据库，并检索了所有与“头皮受累银屑病”相关的文章并用于本综述的撰写。支持Cal/BD气雾剂泡沫对头皮银屑病患者临床有效性、耐受性及对健康结局影响的证据来自一项II期临床试验、一项非干预性研究的真实世界证据数据以及两个病例系列。这些研究的结果表明，Cal/BD气雾剂泡沫起效迅速，可改善皮肤状况，缓解瘙痒等症状，并对患者生活质量产生积极影响。这些特性满足了头皮受累银屑病患者的多项未满足需求，并有可能提高个体治疗依从性。
