Hadjiconstantinou M, Cavalla D, Anthoupoulou E, Laird H E, Neff N H
J Neurochem. 1985 Dec;45(6):1957-9. doi: 10.1111/j.1471-4159.1985.tb10558.x.
The neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces neuropathology and clinical symptoms that resemble Parkinsonism in primates and humans. In mice it induces a long-lasting depletion of neostriatal 3,4-dihydroxyphenylethylamine (dopamine) content. Using the mouse, we found that MPTP induces a fall of dopamine and a rise of acetylcholine in the neostriatum. Both responses to MPTP can be blocked by prior treatment with atropine or trihexyphenidyl.
神经毒素N-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）会引发神经病理学变化以及与灵长类动物和人类帕金森症相似的临床症状。在小鼠中，它会导致新纹状体中3,4-二羟基苯乙胺（多巴胺）含量长期耗竭。利用小鼠，我们发现MPTP会致使新纹状体中多巴胺水平下降以及乙酰胆碱水平上升。对MPTP的这两种反应均可被事先用阿托品或苯海索治疗所阻断。
