细胞周期调控在健康与疾病中的作用——病理医师实用指南

: governor of the cell cycle in health and disease-a primer for the practising pathologist.

机构信息

Department of Pathology, Ghent University Hospital, Ghent, Belgium.

Department of Pathology, Ghent University Hospital, Ghent, Belgium

出版信息

J Clin Pathol. 2024 Jun 19;77(7):435-438. doi: 10.1136/jcp-2024-209480.

DOI:10.1136/jcp-2024-209480

PMID:38772617

Abstract

stands as the pioneering discovery in tumour-suppressor genes, marking a pivotal breakthrough in comprehending cancer development. This overview delves into the role of in both health and disease, exploring its association with the tumourigenesis of various cancers and a distinct subset of soft-tissue neoplasms. Additionally, we discuss the application of immunohistochemistry and fluorescence in situ hybridisation to detect alterations.

摘要

作为肿瘤抑制基因的开创性发现，它标志着理解癌症发展的一个关键突破。本篇综述深入探讨了在健康和疾病中的作用，研究了它与各种癌症和一组独特的软组织肿瘤的肿瘤发生的关联。此外，我们还讨论了应用免疫组织化学和荧光原位杂交来检测的改变。