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经双侧腋窝乳晕入路行机器人甲状腺切除术治疗 4cm 以上甲状腺肿瘤的手术效果。

Surgical outcomes of robotic thyroidectomy for thyroid tumors over 4 cm via the bilateral axillo-breast approach.

机构信息

Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, South Korea.

Department of Surgery, Tan Tock Seng Hospital, Singapore, Singapore.

出版信息

Sci Rep. 2024 May 21;14(1):11646. doi: 10.1038/s41598-024-62021-2.

DOI:10.1038/s41598-024-62021-2
PMID:38773181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11109269/
Abstract

The study investigated the feasibility of robotic bilateral axillo-breast approach (BABA) thyroidectomy for patients with thyroid tumors larger than 4 cm. BABA thyroidectomy has previously shown safety and effectiveness for thyroid surgeries but lacked extensive data on its application to larger tumors. Between October 2008 and August 2022, there were 74 patients underwent robotic BABA thyroidectomy due to thyroid nodules exceeding 4 cm in size. The mean patient age was 40.3 years. Fine needle aspiration results classified the tumors as benign (50.0%), atypia of undetermined significance (27.0%), follicular neoplasm (16.2%), suspicious for malignancy/malignancy (5.4%), or lymphoma (1.4%). The average tumor size was 4.9 cm, with the majority (85.1%) undergoing thyroid lobectomy, and the rest (14.9%) receiving total thyroidectomy. The mean total operation time was 178.4 min for lobectomy and 207.3 min for total thyroidectomy. Transient vocal cord palsy (VCP) was found in 3 patients (4.1%), and there was no permanent VCP. Among patients who underwent total thyroidectomy, transient hypoparathyroidism was observed in three (27.2%), and permanent hypoparathyroidism was observed in one (9.1%). There were no cases of open conversion, tumor spillage, bleeding, flap injury, or tumor recurrence. In conclusion, robotic BABA thyroidectomy may be a safe treatment option for large-sized thyroid tumors that carries no significant increase in complication rates.

摘要

本研究旨在探讨机器人双侧腋窝入路(Bilateral Axillo-breast Approach,BABA)甲状腺切除术治疗直径大于 4cm 甲状腺肿瘤的可行性。BABA 甲状腺切除术在甲状腺手术中已显示出安全性和有效性,但缺乏其在较大肿瘤应用方面的广泛数据。2008 年 10 月至 2022 年 8 月,共有 74 例因甲状腺结节大于 4cm 而接受机器人 BABA 甲状腺切除术的患者。患者平均年龄为 40.3 岁。细针穿刺结果将肿瘤分为良性(50.0%)、意义未明的非典型增生(27.0%)、滤泡性肿瘤(16.2%)、疑似恶性/恶性(5.4%)和淋巴瘤(1.4%)。肿瘤平均大小为 4.9cm,其中 85.1%行甲状腺叶切除术,其余 14.9%行甲状腺全切除术。甲状腺叶切除术的平均总手术时间为 178.4 分钟,甲状腺全切除术的平均总手术时间为 207.3 分钟。3 例(4.1%)患者出现暂时性声带麻痹(Vocal Cord Palsy,VCP),无永久性 VCP。行甲状腺全切除术的患者中,暂时性甲状旁腺功能减退 3 例(27.2%),永久性甲状旁腺功能减退 1 例(9.1%)。无中转开放、肿瘤溢出、出血、皮瓣损伤或肿瘤复发的病例。总之,机器人 BABA 甲状腺切除术可能是治疗大尺寸甲状腺肿瘤的一种安全选择,不会显著增加并发症发生率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecbb/11109269/038e53b9d712/41598_2024_62021_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecbb/11109269/1194bd71c02d/41598_2024_62021_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecbb/11109269/038e53b9d712/41598_2024_62021_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecbb/11109269/1194bd71c02d/41598_2024_62021_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecbb/11109269/038e53b9d712/41598_2024_62021_Fig2_HTML.jpg

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Cancers (Basel). 2023 May 26;15(11):2931. doi: 10.3390/cancers15112931.
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Robotic transaxillary thyroidectomy: time to expand indications?机器人经锁骨下入路甲状腺切除术:扩大适应证的时机?
J Robot Surg. 2023 Aug;17(4):1777-1785. doi: 10.1007/s11701-023-01594-y. Epub 2023 Apr 17.
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Mapping global epidemiology of thyroid nodules among general population: A systematic review and meta-analysis.
普通人群甲状腺结节的全球流行病学图谱:一项系统评价与荟萃分析。
Front Oncol. 2022 Nov 10;12:1029926. doi: 10.3389/fonc.2022.1029926. eCollection 2022.
4
Safety and Feasibility of Robotic Transaxillary Thyroidectomy for Graves' Disease: A Retrospective Cohort Study.机器人经腋窝入路甲状腺切除术治疗格雷夫斯病的安全性和可行性:一项回顾性队列研究。
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Single Surgeon Experience with 500 Cases of the Robotic Bilateral Axillary Breast Approach (BABA) for Thyroid Surgery Using the Da-Vinci Xi System.单名外科医生使用达芬奇Xi系统经双侧腋窝入路机器人辅助甲状腺手术500例的经验
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