来特莫韦用于异基因造血细胞移植儿童的巨细胞病毒预防。 - Suppr

Letermovir as cytomegalovirus prophylaxis in children undergoing allogeneic hematopoietic cell transplantation.

作者信息

Pfeiffer Thomas, Lockowitz Christine R, Shenoy Shalini, Mavers Melissa, Hayashi Robert, Bednarski Jeffrey, Green Abby

机构信息

Department of Pediatrics, Division of Hematology/Oncology, Washington University School of Medicine, St. Louis, MO, USA.

Department of Pharmacy, St. Louis Children's Hospital, St. Louis, MO, USA.

出版信息

Bone Marrow Transplant. 2024 Aug;59(8):1193-1195. doi: 10.1038/s41409-024-02315-1. Epub 2024 May 21.

DOI:10.1038/s41409-024-02315-1

PMID:38773282

Abstract

摘要

相似文献

Letermovir as cytomegalovirus prophylaxis in children undergoing allogeneic hematopoietic cell transplantation.来特莫韦用于异基因造血细胞移植儿童的巨细胞病毒预防。

Bone Marrow Transplant. 2024 Aug;59(8):1193-1195. doi: 10.1038/s41409-024-02315-1. Epub 2024 May 21.

Assessment of Cytomegalovirus DNA doubling time and virus-specific T-cell responses in the management of CMV infection in allogeneic hematopoietic stem cell transplant recipients undergoing Letermovir prophylaxis.在接受来特莫韦预防治疗的异基因造血干细胞移植受者巨细胞病毒感染管理中评估巨细胞病毒DNA倍增时间和病毒特异性T细胞反应。

Bone Marrow Transplant. 2024 Oct;59(10):1480-1482. doi: 10.1038/s41409-024-02376-2. Epub 2024 Jul 20.

Letermovir at a Prophylactic Dose for Cytomegalovirus Infection in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Single-Center Retrospective Study in Japan.来特莫韦预防剂量用于异基因造血干细胞移植儿童的巨细胞病毒感染：日本单中心回顾性研究。

Biol Pharm Bull. 2024;47(9):1575-1582. doi: 10.1248/bpb.b24-00217.

Role of letermovir for prevention of cytomegalovirus infection after allogeneic haematopoietic stem cell transplantation.来特莫韦在异基因造血干细胞移植后预防巨细胞病毒感染中的作用。

Curr Opin Infect Dis. 2018 Aug;31(4):286-291. doi: 10.1097/QCO.0000000000000459.

Comparative Efficacy and Safety of Different Antiviral Agents for Cytomegalovirus Prophylaxis in Allogeneic Hematopoietic Cell Transplantation: A Systematic Review and Meta-Analysis.异基因造血细胞移植中细胞巨化病毒预防的不同抗病毒药物的疗效和安全性比较：系统评价和荟萃分析。

Biol Blood Marrow Transplant. 2018 Oct;24(10):2101-2109. doi: 10.1016/j.bbmt.2018.05.017. Epub 2018 May 16.

Letermovir for Cytomegalovirus Prevention in Adolescent Patients Following Hematopoietic Cell Transplantation.来特莫韦预防造血干细胞移植后青少年患者巨细胞病毒感染。

J Pediatric Infect Dis Soc. 2022 Jul 21;11(7):337-340. doi: 10.1093/jpids/piac017.

Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation.来特莫韦预防造血干细胞移植后巨细胞病毒感染。

N Engl J Med. 2017 Dec 21;377(25):2433-2444. doi: 10.1056/NEJMoa1706640. Epub 2017 Dec 6.

Real-world experience with letermovir for cytomegalovirus-prophylaxis after allogeneic hematopoietic cell transplantation: A multi-centre observational study.来特莫韦用于异基因造血细胞移植后巨细胞病毒预防的真实世界经验：一项多中心观察性研究。

J Infect. 2024 Aug;89(2):106220. doi: 10.1016/j.jinf.2024.106220. Epub 2024 Jul 1.

Letermovir (Prevymis) for CMV prophylaxis.来特莫韦（普瑞明）用于巨细胞病毒预防。

Med Lett Drugs Ther. 2019 Dec 16;61(1587):199-201.

Letermovir for prophylaxis of cytomegalovirus in allogeneic hematopoietic stem cell recipients.来特莫韦用于异基因造血干细胞移植受者预防巨细胞病毒感染

Drugs Today (Barc). 2018 Jun;54(6):361-368. doi: 10.1358/dot.2018.54.6.2833982.

引用本文的文献

Efficacy and Safety of Letermovir for Cytomegalovirus Prophylaxis Following Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients.来特莫韦用于儿童患者异基因造血干细胞移植后巨细胞病毒预防的疗效和安全性

Drug Des Devel Ther. 2025 Jun 12;19:5059-5069. doi: 10.2147/DDDT.S513383. eCollection 2025.

Cytomegalovirus infection and drug resistance emergence during letermovir salvage therapy in a pediatric SCID patient.一名儿科重症联合免疫缺陷病（SCID）患者在使用来特莫韦挽救治疗期间出现巨细胞病毒感染及耐药情况。

NPJ Antimicrob Resist. 2025 May 28;3(1):43. doi: 10.1038/s44259-025-00118-y.

Efficacy and safety of primary letermovir prophylaxis for cytomegalovirus infection in paediatric patients undergoing allogeneic transplantation: a single-centre, retrospective, real-world analysis.来特莫韦对接受异基因移植的儿科患者巨细胞病毒感染进行一级预防的疗效和安全性：一项单中心、回顾性、真实世界分析。

Clin Hematol Int. 2025 Mar 14;7(1):36-46. doi: 10.46989/001c.131683. eCollection 2025.

本文引用的文献

CMV Infection After Letermovir Primary Prophylaxis Discontinuation in Allogeneic Hematopoietic Cell Transplant Recipients.异基因造血细胞移植受者停用来特莫韦一级预防后的巨细胞病毒感染

Open Forum Infect Dis. 2023 Mar 27;10(4):ofad169. doi: 10.1093/ofid/ofad169. eCollection 2023 Apr.

Viral Infections in HSCT: Detection, Monitoring, Clinical Management, and Immunologic Implications.造血干细胞移植中的病毒感染：检测、监测、临床管理及免疫学意义

Front Immunol. 2021 Jan 20;11:569381. doi: 10.3389/fimmu.2020.569381. eCollection 2020.

How I treat CMV reactivation after allogeneic hematopoietic stem cell transplantation.异基因造血干细胞移植后 CMV 再激活的治疗策略

Blood. 2020 May 7;135(19):1619-1629. doi: 10.1182/blood.2019000956.

Outcomes of patients with detectable CMV DNA at randomization in the phase III trial of letermovir for the prevention of CMV infection in allogeneic hematopoietic cell transplantation.在来特莫韦预防异基因造血细胞移植中巨细胞病毒感染的III期试验中，随机分组时检测到巨细胞病毒DNA的患者的结局。

Am J Transplant. 2020 Jun;20(6):1703-1711. doi: 10.1111/ajt.15764. Epub 2020 Jan 18.

Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation.来特莫韦预防造血干细胞移植后巨细胞病毒感染。

N Engl J Med. 2017 Dec 21;377(25):2433-2444. doi: 10.1056/NEJMoa1706640. Epub 2017 Dec 6.

Risk for CMV reactivation in children undergoing allogeneic hematopoietic stem cell transplantation.接受异基因造血干细胞移植的儿童中巨细胞病毒再激活的风险。

Pediatr Blood Cancer. 2015 Feb;62(2):364-366. doi: 10.1002/pbc.25237. Epub 2014 Sep 27.

Evidence for a bidirectional relationship between cytomegalovirus replication and acute graft-versus-host disease.巨细胞病毒复制与急性移植物抗宿主病之间存在双向关系的证据。

Biol Blood Marrow Transplant. 2010 Sep;16(9):1309-14. doi: 10.1016/j.bbmt.2010.03.020. Epub 2010 Mar 29.

In vitro and in vivo activities of the novel anticytomegalovirus compound AIC246.新型抗巨细胞病毒化合物 AIC246 的体外和体内活性。

Antimicrob Agents Chemother. 2010 Mar;54(3):1290-7. doi: 10.1128/AAC.01596-09. Epub 2010 Jan 4.

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