Boechat M I, Ortega J, Hoffman A D, Cleveland R H, Kangarloo H, Gilsanz V
AJR Am J Roentgenol. 1985 Dec;145(6):1283-7. doi: 10.2214/ajr.145.6.1283.
This multicenter study was designed to determine if CT can assess operability in stage III neuroblastoma. Nineteen children (11 boys, eight girls), aged 2-51 months, considered to have, by conventional clinical and radiographic examinations, localized neuroblastoma that crossed the midline were examined by CT. After intravenous and oral contrast media enhancements, CT was able to show the relation of the tumor to the adjacent vital vessels: aorta, celiac axis, and superior mesenteric artery. In all 15 patients, tumors that encased the aorta or its major branches were unresectable. However, three of four tumors crossing the midline but not coming into contact with the aorta or adherent only to one side of the vessel could be resected. Because surgery currently plays the major role in the treatment of neuroblastoma, the relation of the tumor to the aorta and great vessels is a more reliable and important factor in predicting the outcome of these children than the extension and location of the tumor with reference to the midline. CT after intravenous contrast enhancement can establish this relation and assess resectability.
这项多中心研究旨在确定CT能否评估Ⅲ期神经母细胞瘤的可切除性。19名年龄在2至51个月的儿童（11名男孩，8名女孩），经传统临床和影像学检查被认为患有跨越中线的局限性神经母细胞瘤，接受了CT检查。经静脉和口服造影剂增强后，CT能够显示肿瘤与相邻重要血管（主动脉、腹腔干和肠系膜上动脉）的关系。在所有15例患者中，包绕主动脉或其主要分支的肿瘤无法切除。然而，4例跨越中线但未与主动脉接触或仅附着于血管一侧的肿瘤中有3例可以切除。由于目前手术在神经母细胞瘤的治疗中起主要作用，与肿瘤相对于中线的延伸和位置相比，肿瘤与主动脉及大血管的关系是预测这些儿童预后更可靠且更重要的因素。静脉注射造影剂增强后的CT能够确定这种关系并评估可切除性。
