Spier C M, Kjeldsberg C R, Head D R, DiFiore K C, Tudor B
Am J Clin Pathol. 1985 Nov;84(5):675-8. doi: 10.1093/ajcp/84.5.675.
The occurrence of chronic lymphocytic leukemia (CLL), B-cell type, is thought to be distinctly uncommon in patients younger than 40 years of age. Previous case reports of CLL in young adults and children were published before the widespread use of immunologic surface markers in the diagnosis of lymphoproliferative disorders. The authors report four patients with B-cell CLL, all diagnosed with the aid of immunologic markers. The patients were 30 years of age or younger at the time of diagnosis. Their subsequent course has been similar to B-cell CLL in the older age group: one is alive without progression of disease 30 months after diagnosis; one has shown progression of the disease but is alive, after chemotherapy, 36 months after diagnosis; while the other two had continued progression of disease and died, one at six and a half years and the other at 14 months, after diagnosis. The occurrence of B-cell CLL in young adults and its potential implications are discussed.
B细胞型慢性淋巴细胞白血病（CLL）在40岁以下患者中的发生率被认为明显较低。以往关于年轻成人和儿童CLL的病例报告是在免疫表面标志物广泛用于诊断淋巴增殖性疾病之前发表的。作者报告了4例B细胞型CLL患者，均借助免疫标志物得以确诊。这些患者在诊断时年龄均为30岁或更小。他们随后的病程与老年组B细胞型CLL相似：1例在诊断后30个月存活且疾病无进展；1例疾病出现进展，但在化疗后，诊断后36个月仍存活；而另外2例疾病持续进展并死亡，1例在诊断后6年半死亡，另1例在14个月后死亡。本文讨论了年轻成人中B细胞型CLL的发生情况及其潜在意义。
