脑静脉窦血栓形成中的脱水。
Dehydration in cerebral venous sinus thrombosis.
机构信息
Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
出版信息
CNS Neurosci Ther. 2024 May;30(5):e14760. doi: 10.1111/cns.14760.
AIMS
This study aimed to unravel the dehydration status of patients with cerebral venous sinus thrombosis (CVST) to facilitate the understanding of dehydration in CVST.
METHODS
This was a multicenter retrospective study and three populations were recruited, namely, patients with CVST, CVST mimics, and healthy subjects. Blood samples were obtained 1-2 days after admission to assess dehydration status. Stata 15.1 was performed for statistical analysis.
RESULTS
A total of 208 patients were diagnosed with CVST, 237 with CVST mimics, and 200 healthy individuals were enrolled. The urine specific gravity (USG, 1.020 [1.014, 1.029] vs. 1.017 [1.011, 1.021]) was higher in patients with CVST than in those with mimics (all p < 0.001). The percentage of USG >1.03 was also higher in CVST (22.6%) than in its mimics (6.3%, p < 0.001). With the development of CVST, USG (acute vs. sub-acute vs. chronic, 1.022 [1.015, 1.033] vs. 1.021 [1.015, 1.031] vs. 1.019 [1.014, 1.025]) decreased. All dehydration-related markers could not differentiate CVST from its mimics and healthy populations, and they were not associated with CVST severity and prognosis (p > 0.05).
CONCLUSION
High levels of USG, especially USG >1.013, were more common in patients with CVST. Dehydration-related indices could not characterize CVST and were not associated with CVST severity and prognosis.
目的
本研究旨在阐明脑静脉窦血栓形成（CVST）患者的脱水状态，以帮助理解 CVST 中的脱水现象。
方法
这是一项多中心回顾性研究，共纳入了三组人群，即 CVST 患者、CVST 模拟患者和健康对照者。患者在入院后 1-2 天内采集血样以评估脱水状态。采用 Stata 15.1 进行统计分析。
结果
共纳入 208 例 CVST 患者、237 例 CVST 模拟患者和 200 例健康对照者。CVST 患者的尿比重（USG，1.020[1.014,1.029]比 1.017[1.011,1.021]）高于 CVST 模拟患者（均 P<0.001）。USG>1.03 的患者在 CVST 组中的比例（22.6%）也高于 CVST 模拟患者（6.3%，P<0.001）。随着 CVST 的发展，USG（急性组比亚急性组比慢性组，1.022[1.015,1.033]比 1.021[1.015,1.031]比 1.019[1.014,1.025]）逐渐降低。所有与脱水相关的标志物均不能区分 CVST 与 CVST 模拟患者和健康人群，且与 CVST 严重程度和预后无关（P>0.05）。
结论
CVST 患者中更常见高 USG，尤其是 USG>1.013。与脱水相关的指标不能明确 CVST 的特征，且与 CVST 严重程度和预后无关。
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