β-地中海贫血特征患者的铁过载：特发性血色素沉着症基因的作用。
Iron overload in subjects with beta-thalassaemia trait: role of idiopathic haemochromatosis gene.
作者信息
Fargion S, Piperno A, Panaiotopoulos N, Taddei M T, Fiorelli G
出版信息
Br J Haematol. 1985 Nov;61(3):487-90. doi: 10.1111/j.1365-2141.1985.tb02852.x.
Abstract
We have characterized HLA antigens in subjects with beta-thalassaemia trait with and without iron overload. 50% of the cases with iron overload (v 18% of those without iron overload, P less than 0.01) are carriers of HLA-A3, the HLA antigen tightly linked to the IH allele. Thus, in a considerable number of these subjects, beta-thalassaemia and IH coexist. This association exerts a synergistic effect in inducing iron overload.
摘要
我们已对有和没有铁过载的β-地中海贫血特征患者的HLA抗原进行了表征。50%有铁过载的病例（相比之下，没有铁过载的病例中这一比例为18%，P<0.01）是HLA-A3的携带者，HLA-A3是与IH等位基因紧密连锁的HLA抗原。因此，在相当数量的这些患者中，β-地中海贫血和IH共存。这种关联在诱导铁过载方面发挥协同作用。
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