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B型单胺氧化酶的特异性底物苯乙胺对小鼠MPTP多巴胺能毒性的预防作用

Prevention of dopaminergic toxicity of MPTP in mice by phenylethylamine, a specific substrate of type B monoamine oxidase.

作者信息

Melamed E, Youdim M B

出版信息

Br J Pharmacol. 1985 Nov;86(3):529-31. doi: 10.1111/j.1476-5381.1985.tb08927.x.

DOI:10.1111/j.1476-5381.1985.tb08927.x
PMID:3877535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1916713/
Abstract

N-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) is toxic to dopaminergic neurones in several mammalian species including mice. Combined treatment with phenylethylamine prevented in mice the long-term (30 days post-treatment) dopamine depletions in striatum induced by MPTP. Phenylethylamine, a naturally-occurring specific substrate of monoamine oxidase (MAO) type B, probably protects against effects of MPTP by competitively inhibiting the oxidative conversion of MPTP to its toxic metabolite N-methyl-4-phenylpyridinium ion catalysed by MAO-B.

摘要

N-甲基-4-苯基-1,2,5,6-四氢吡啶（MPTP）对包括小鼠在内的几种哺乳动物的多巴胺能神经元有毒性。苯乙胺联合治疗可防止小鼠纹状体中由MPTP诱导的长期（治疗后30天）多巴胺耗竭。苯乙胺是单胺氧化酶（MAO）B型的一种天然存在的特异性底物，可能通过竞争性抑制MAO-B催化的MPTP氧化转化为其有毒代谢物N-甲基-4-苯基吡啶离子来保护机体免受MPTP的影响。

相似文献

1
Prevention of dopaminergic toxicity of MPTP in mice by phenylethylamine, a specific substrate of type B monoamine oxidase.B型单胺氧化酶的特异性底物苯乙胺对小鼠MPTP多巴胺能毒性的预防作用
Br J Pharmacol. 1985 Nov;86(3):529-31. doi: 10.1111/j.1476-5381.1985.tb08927.x.
2
Role for monoamine oxidase-A (MAO-A) in the bioactivation and nigrostriatal dopaminergic neurotoxicity of the MPTP analog, 2'Me-MPTP.单胺氧化酶A（MAO-A）在MPTP类似物2'-甲基-4-苯基-1,2,3,6-四氢吡啶（2'Me-MPTP）的生物活化及黑质纹状体多巴胺能神经毒性中的作用
Eur J Pharmacol. 1988 Feb 9;146(2-3):313-8. doi: 10.1016/0014-2999(88)90308-1.
3
Comparison of the effects of two 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs, 1-methyl-4-(2-thienyl)-1,2,3,6-tetrahydropyridine and 1-methyl-4-(3-thienyl)-1,2,3,6-tetrahydropyridine, on monoamine oxidase in vitro and on dopamine in mouse brain.两种1-甲基-4-苯基-1,2,3,6-四氢吡啶类似物，即1-甲基-4-(2-噻吩基)-1,2,3,6-四氢吡啶和1-甲基-4-(3-噻吩基)-1,2,3,6-四氢吡啶，对体外单胺氧化酶及小鼠脑内多巴胺作用的比较
J Pharmacol Exp Ther. 1987 Feb;240(2):415-20.
4
Monoamine oxidase B(MAO-B) is the major catalyst for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oxidation in human brain and other tissues.单胺氧化酶B（MAO-B）是人类大脑和其他组织中1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）氧化的主要催化剂。
Neurosci Lett. 1986 Feb 28;64(2):216-20. doi: 10.1016/0304-3940(86)90103-5.
5
Evaluation of the biological activity of several analogs of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
J Neurochem. 1987 Mar;48(3):929-34. doi: 10.1111/j.1471-4159.1987.tb05606.x.
6
Deprenyl antagonizes acute lethality of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.司来吉兰可拮抗1-甲基-4-苯基-1,2,3,6-四氢吡啶对小鼠的急性致死作用。
J Pharmacol Exp Ther. 1988 Nov;247(2):531-5.
7
Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) in the mouse: relationships between monoamine oxidase, MPTP metabolism and neurotoxicity.
Life Sci. 1985 Jan 21;36(3):231-6. doi: 10.1016/0024-3205(85)90064-5.
8
Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors.单胺氧化酶抑制剂对1-甲基-4-苯基-1,2,5,6-四氢吡啶多巴胺能神经毒性的保护作用。
Nature. 1984;311(5985):467-9. doi: 10.1038/311467a0.
9
Astrocytes as a primary locus for the conversion MPTP into MPP+.星形胶质细胞作为将MPTP转化为MPP +的主要场所。
J Neural Transm. 1989;76(1):1-12. doi: 10.1007/BF01244987.
10
MPTP toxicity in relation to age, dopamine uptake and MAO-B activity in two rodent species.两种啮齿动物中与年龄、多巴胺摄取及单胺氧化酶B活性相关的1-甲基-4-苯基-1,2,3,6-四氢吡啶毒性
Pharmacol Toxicol. 1989 Mar;64(3):314-8. doi: 10.1111/j.1600-0773.1989.tb00654.x.

引用本文的文献

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The Effect of Neurotoxin MPTP and Neuroprotector Isatin on the Profile of Ubiquitinated Brain Mitochondrial Proteins.神经毒素MPTP和神经保护剂异吲哚酮对泛素化脑线粒体蛋白谱的影响。
Cells. 2018 Jul 31;7(8):91. doi: 10.3390/cells7080091.
2
Monoamine oxidase: isoforms and inhibitors in Parkinson's disease and depressive illness.单胺氧化酶：帕金森病和抑郁症中的同工型与抑制剂
Br J Pharmacol. 2006 Jan;147 Suppl 1(Suppl 1):S287-96. doi: 10.1038/sj.bjp.0706464.
3
Intracerebroventricular administration of 1-methyl-4-phenylpyridinium ion in mice: effects of simultaneously administered nomifensine, deprenyl, and 1-t-butyl-4,4-diphenylpiperidine.小鼠脑室内注射1-甲基-4-苯基吡啶离子：同时给予诺米芬辛、司来吉兰和1-叔丁基-4,4-二苯基哌啶的影响
J Neural Transm. 1988;71(3):177-88. doi: 10.1007/BF01245711.
4
Oxidation and enzyme-activated irreversible inhibition of rat liver monoamine oxidase-B by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）对大鼠肝脏单胺氧化酶-B的氧化及酶激活不可逆抑制作用
Biochem J. 1986 Dec 1;240(2):379-83. doi: 10.1042/bj2400379.

本文引用的文献

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Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice.1-甲基-4-苯基-1,2,5,6-四氢吡啶对小鼠的多巴胺能神经毒性
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Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors.单胺氧化酶抑制剂对1-甲基-4-苯基-1,2,5,6-四氢吡啶多巴胺能神经毒性的保护作用。
Nature. 1984;311(5985):467-9. doi: 10.1038/311467a0.
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Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism.神经元内吡啶代谢物的生成可能导致药物性帕金森综合征。
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High-affinity binding sites for [3H]MPTP may correspond to monamine oxidase.[3H]MPTP的高亲和力结合位点可能与单胺氧化酶相对应。
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Pargyline prevents MPTP-induced parkinsonism in primates.帕吉林可预防灵长类动物中由1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱发的帕金森症。
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