B型单胺氧化酶的特异性底物苯乙胺对小鼠MPTP多巴胺能毒性的预防作用
Prevention of dopaminergic toxicity of MPTP in mice by phenylethylamine, a specific substrate of type B monoamine oxidase.
作者信息
Melamed E, Youdim M B
出版信息
Br J Pharmacol. 1985 Nov;86(3):529-31. doi: 10.1111/j.1476-5381.1985.tb08927.x.
Abstract
N-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) is toxic to dopaminergic neurones in several mammalian species including mice. Combined treatment with phenylethylamine prevented in mice the long-term (30 days post-treatment) dopamine depletions in striatum induced by MPTP. Phenylethylamine, a naturally-occurring specific substrate of monoamine oxidase (MAO) type B, probably protects against effects of MPTP by competitively inhibiting the oxidative conversion of MPTP to its toxic metabolite N-methyl-4-phenylpyridinium ion catalysed by MAO-B.
摘要
N-甲基-4-苯基-1,2,5,6-四氢吡啶（MPTP）对包括小鼠在内的几种哺乳动物的多巴胺能神经元有毒性。苯乙胺联合治疗可防止小鼠纹状体中由MPTP诱导的长期（治疗后30天）多巴胺耗竭。苯乙胺是单胺氧化酶（MAO）B型的一种天然存在的特异性底物，可能通过竞争性抑制MAO-B催化的MPTP氧化转化为其有毒代谢物N-甲基-4-苯基吡啶离子来保护机体免受MPTP的影响。
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