Narula Neeraj, Hamam Hasan, Peerani Farhad, Bessissow Talat, Bressler Brian, Dulai Parambir S
McMaster University Medical Centre, Hamilton, Ontario, Canada.
Division of Gastroenterology, University of Alberta Hospital, Edmonton, Alberta, Canada.
Am J Gastroenterol. 2024 Sep 1;119(9):1939-1942. doi: 10.14309/ajg.0000000000002860. Epub 2024 May 8.
This study assesses 2 different disease activity measures, the Modified Truelove Witts Severity Index and the partial Mayo score, in hospitalized patients with acute severe ulcerative colitis (UC) for prediction of postdischarge corticosteroid-free clinical remission and endoscopic improvement to help guide future considerations for disease activity assessment. In this post hoc analysis from the Tofacitinib for Hospitalized Acute Severe Ulcerative Colitis Management (TRIUMPH) trial, these results suggest resolution of the Mayo rectal bleeding subscore may have high prognostic utility and could be considered as a primary end point for hospitalized UC trials. The study underscores the need for further research on patient-reported outcomes and endoscopic indices in larger populations for inpatient UC trials.
本研究评估了两种不同的疾病活动度测量方法，即改良的 Truelove Witts 严重程度指数和部分梅奥评分，用于预测急性重症溃疡性结肠炎（UC）住院患者出院后无皮质类固醇临床缓解和内镜改善情况，以帮助指导未来疾病活动度评估的考量。在这项来自托法替布治疗住院急性重症溃疡性结肠炎管理（TRIUMPH）试验的事后分析中，这些结果表明梅奥直肠出血子评分的改善可能具有较高的预后价值，可被视为住院 UC 试验的主要终点。该研究强调了在更大规模人群中对住院 UC 试验的患者报告结局和内镜指标进行进一步研究的必要性。
