Clin Nucl Med. 2024 Jul 1;49(7):e329-e330. doi: 10.1097/RLU.0000000000005273. Epub 2024 May 23.
Neuroendocrine tumor (NET) typically spreads to the liver, lymph nodes, lungs, and skeleton. Brain metastasis in NET is uncommon. Therefore, each case of detected brain metastases in NET is crucial for the development of treatment guidelines for these types of tumors. We present a unique case of triple tumors (NET, papillary thyroid carcinoma, and schwannoma) in a single patient who presented with neurological symptoms and somatostatin receptor-avid T2 hyperintense multiple metastatic brain lesions from NET on 68 Ga-DOTATATE-PET/CT scan and brain MRI. Despite the rarity of brain metastases in NET, we conclude that the presence of neurological sign or symptoms and/or the detection of somatostatin receptor-avid brain lesions in patients with NET should raise suspicion of brain metastases.
神经内分泌肿瘤（NET）通常会扩散到肝脏、淋巴结、肺部和骨骼。NET 发生脑转移并不常见。因此，NET 患者中每一例检测到的脑转移都对这些类型肿瘤的治疗指南的制定至关重要。我们报告了一例独特的三瘤（NET、甲状腺乳头状癌和神经鞘瘤）共存于单一患者的病例，该患者因神经症状就诊，68Ga-DOTATATE-PET/CT 扫描和脑部 MRI 显示 NET 所致的生长抑素受体阳性 T2 高信号多发脑转移瘤。尽管 NET 脑转移罕见，但我们得出结论，NET 患者出现神经症状或体征和/或检测到生长抑素受体阳性脑转移瘤时，应怀疑脑转移。
