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恶性肿瘤?髓脂肪瘤导致儿童股骨病理性骨折:一例报告并文献复习

Malicious Tumor? Pathological Fracture of the Femur in Children Caused by Myelolipoma: A Case Report and Review of Literatures.

作者信息

Shen Xiaoyu, Yao Qiang, Qi Xiangbei, Ma Lijie

机构信息

Department of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang 050035, China.

Internal Medicine, The First Hospital of Hebei Medical University, Shijiazhuang 050000, China.

出版信息

Case Rep Oncol Med. 2024 May 15;2024:5838618. doi: 10.1155/2024/5838618. eCollection 2024.

Abstract

Myelolipoma is a kind of benign lipoma containing myeloid cells. It is a rare type of tumor that typically presents as an occasional adrenal tumor, generally manifesting as a nonfunctional adrenal mass. Although it can occur in extra-adrenal tissues, its occurrence in bone tissue is extremely rare. Most cases are discovered accidentally during physical examinations of adults, and there are currently no reports of cases with pathological fractures as the main symptoms. We present a case of a 15-year-old teenager who developed a pathological fracture caused by femoral myelolipoma. The diagnosis of the specific type of bone tumor of the patient was determined through pathology and imaging. To treat the condition, we utilized a technique known as the "soft drill" to fully access the tumor space, remove the bone septum, and scrape away the diseased tissue. The fracture was then stabilized using a hybrid external fixation. After a 2-year follow-up period, there was no recurrence of the bone tumor. This case is the first case of intraosseous myelolipoma that occurred in a minor with the initial symptom of pathological fracture, filling the gap in our existing body of knowledge and providing a reference for the treatment of this type of intraosseous myelolipoma.

摘要

髓脂肪瘤是一种含有骨髓细胞的良性脂肪瘤。它是一种罕见的肿瘤类型,通常表现为偶发的肾上腺肿瘤,一般表现为无功能的肾上腺肿块。虽然它可发生于肾上腺外组织,但其在骨组织中的发生极为罕见。大多数病例是在成人体检时偶然发现的,目前尚无以病理性骨折为主要症状的病例报告。我们报告一例15岁青少年因股骨髓脂肪瘤导致病理性骨折的病例。通过病理和影像学检查确定了该患者骨肿瘤的具体类型。为治疗该疾病,我们采用了一种称为“软钻”的技术,以充分进入肿瘤空间,去除骨间隔,并刮除病变组织。然后使用混合外固定器固定骨折部位。经过2年的随访期,骨肿瘤未复发。该病例是首例以病理性骨折为首发症状发生在未成年人的骨内髓脂肪瘤,填补了我们现有知识体系中的空白,并为这类骨内髓脂肪瘤的治疗提供了参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6107/11111296/44e75c507ba5/CRIONM2024-5838618.001.jpg

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