Xie Yang, Tang Wenxin, Ma Jiao, Chen Yue
Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, China.
Front Oncol. 2024 May 8;14:1373286. doi: 10.3389/fonc.2024.1373286. eCollection 2024.
This study aimed to investigate the characteristics of various pulmonary lesions as revealed by Ga-FAPI PET/CT and to determine the utility of Ga-FAPI PET/CT in distinguishing the nature of these pulmonary lesions.
A retrospective analysis was conducted on 99 patients with pulmonary lesions, who were categorized into three distinct groups: primary lung tumors (G1), metastatic lung tumors (G2), and benign lesions (G3). Each participant underwent a Ga-FAPI PET/CT scan. Among these groups, variables such as the Tumor/Background Ratio (TBR), Maximum Standardized Uptake Value (SUVmax), and the true positive rate of the lesions were compared. Furthermore, the FAPI uptake in nodular-like pulmonary lesions (d<3cm) and those with irregular borders was evaluated across the groups. A correlation analysis sought to understand the relationship between FAPI uptake in primary and pulmonary metastatic lesions.
The study's participants were composed of 52 males and 47 females, with an average age of 56.8 ± 13.2 years. A higher uptake and detection rate for pulmonary lesions were exhibited by Group G1 compared to the other groups (SUVmax [G1 vs. G2 vs. G3: 9.1 ± 4.1 vs. 6.1 ± 4.1 vs. 5.3 ± 5.8], <0.05; TBR [G1 vs. G2 vs. G3: 6.2 ± 2.4 vs. 4.1 ± 2.2 vs. 3.2 ± 2.7], <0.01; true positive rate 95.1% vs. 88% vs. 75.6%]. In nodular-like lung lesions smaller than 3 cm, G1 showed a significantly higher FAPI uptake compared to G2 and G3 (SUVmax [G1 vs. G2 vs. G3: 8.8 ± 4.3 vs. 5.2 ± 3.2 vs. 4.9 ± 6.1], <0.01; TBR [G1 vs. G2 vs. G3: 5.7 ± 2.7 vs. 3.7 ± 2.1 vs. 3.3 ± 4.4], <0.05). Both G1 and G2 demonstrated significantly elevated FAPI agent activity in irregular-bordered pulmonary lesions when compared to G3 (SUVmax [G1 vs. G2 vs. G3: 10.9 ± 3.3 vs. 8.5 ± 2.7 vs. 4.6 ± 2.7], <0.01; TBR [G1 vs. G2 vs. G3: 7.2 ± 2.1 vs. 6.4 ± 1.3 vs. 3.2 ± 2.4], <0.01). A positive correlation was identified between the level of Ga-FAPI uptake in primary lesions and the uptake in pulmonary metastatic lesions within G2 (r=0.856, <0.05).
Ga-FAPI PET/CT imaging proves to be of significant value in the evaluation of pulmonary lesions, offering distinctive insights into their nature.
本研究旨在探讨镓标记纤维连接蛋白激活肽（Ga-FAPI）PET/CT所显示的各种肺部病变的特征，并确定Ga-FAPI PET/CT在鉴别这些肺部病变性质方面的效用。
对99例肺部病变患者进行回顾性分析，这些患者被分为三个不同的组：原发性肺肿瘤（G1组）、肺转移瘤（G2组）和良性病变（G3组）。每位参与者均接受了Ga-FAPI PET/CT扫描。在这些组中，比较了肿瘤/本底比值（TBR）、最大标准化摄取值（SUVmax）以及病变的真阳性率等变量。此外，还评估了各组中结节状肺部病变（直径<3cm）和边界不规则的病变的FAPI摄取情况。进行相关性分析以了解原发性和肺转移病变中FAPI摄取之间的关系。
研究参与者包括52名男性和47名女性，平均年龄为56.8±13.2岁。与其他组相比，G1组肺部病变的摄取和检出率更高（SUVmax[G1组 vs. G2组 vs. G3组：9.1±4.1 vs. 6.1±4.1 vs. 5.3±5.8]，<0.05；TBR[G1组 vs. G2组 vs. G3组：6.2±2.4 vs. 4.1±2.2 vs. 3.2±2.7]，<0.01；真阳性率95.1% vs. 88% vs. 75.6%]）。在直径小于3cm的结节状肺部病变中，G1组的FAPI摄取明显高于G2组和G3组（SUVmax[G1组 vs. G2组 vs. G3组：8.8±4.3 vs. 5.2±3.2 vs. 4.9±6.1]，<0.01；TBR[G1组 vs. G2组 vs. G3组：5.7±2.7 vs. 3.7±2.1 vs. 3.3±4.4]，<0.05）。与G3组相比，G1组和G2组在边界不规则的肺部病变中FAPI剂活性均显著升高（SUVmax[G1组 vs. G2组 vs. G3组：10.9±3.3 vs. 8.5±2.7 vs. 4.6±2.7]，<0.01；TBR[G1组 vs. G2组 vs. G3组：7.2±2.1 vs. 6.4±1.3 vs. 3.2±2.4]，<0.01）。在G2组中，原发性病变的Ga-FAPI摄取水平与肺转移病变的摄取之间存在正相关（r=0.856，<0.05）。
Ga-FAPI PET/CT成像在评估肺部病变方面具有重要价值，能为其性质提供独特的见解。
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