Bell L M, Alpert G, Campos J M, Plotkin S A
Pediatrics. 1985 Dec;76(6):901-4.
The potential clinical value of quantitative blood cultures determined by a commercially available lysis-direct plating method was studied in 50 children with either Haemophilus influenzae or Streptococcus pneumoniae bacteremia. The magnitude of bacteremia correlated with the severity of the infection; patients with greater than or equal to 100 colony-forming units per milliliter were significantly more likely to have meningitis (P less than .01, chi 2 = 7.5). On the other hand, all patients with S. pneumoniae bacteremia with colony counts lower than 15 colony-forming units per milliliter had "occult bacteremia" with no focus of infection. The data suggest that patients with higher levels of bacteremia have more severe disease. Quantitative blood culture results may be helpful in identifying which children are at risk for invasive disease.
采用市售的裂解直接平板接种法测定定量血培养的潜在临床价值，对50例患有流感嗜血杆菌或肺炎链球菌菌血症的儿童进行了研究。菌血症的程度与感染的严重程度相关；每毫升菌落形成单位大于或等于100的患者发生脑膜炎的可能性显著更高（P<0.01，χ2=7.5）。另一方面，所有肺炎链球菌菌血症菌落计数低于每毫升15个菌落形成单位的患者均有“隐匿性菌血症”，且无感染灶。数据表明，菌血症水平较高的患者病情更严重。定量血培养结果可能有助于识别哪些儿童有发生侵袭性疾病的风险。
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