疟疾可负担药品设施(AMFm)对尼日利亚抗疟药可及性的影响。

Effect of the Affordable Medicines Facility for malaria (AMFm) on the availability of antimalarials in Nigeria.

作者信息

Joda Arinola, Ezeigwe Nnenna, Oguguo Lilian, Taylor Ogori, Ntadom Godwin

机构信息

Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Lagos, Idiaraba Campus, Idiaraba, Lagos, Nigeria.

National Malaria Elimination Program, Federal Ministry of Health, Abuja, Nigeria.

出版信息

Malariaworld J. 2015 May 9;6:5. doi: 10.5281/zenodo.10870095. eCollection 2015.

Abstract

BACKGROUND

Malaria is one of the most important causes of mortality worldwide. Use of the most effective treatments remains inadequate for those in need and there is concern over the emergence of resistance. Rapid, accurate and accessible detection of malaria parasites plays a role in promoting more rational use of increasingly costly drugs in many endemic areas. Rapid diagnostic tests (RDTs) offer the potential to provide accurate diagnosis to all at-risk populations for the first time, reaching those unable to access good quality microscopy services. In 2010, the Global Fund launched the Affordable Medicines Facility for malaria (AMFm) designed to increase access and use of good quality artemisinin-based combination therapies (ACTs) for malaria treatment. AMFm involves manufacturer price negotiations, subsidies and other interventions. The aim of this study was to document the availability of ACTs and RDTs provided under the National Malaria Elimination Programme via the AMFm financing strategy.

MATERIALS AND METHODS

Investigators were systematically selected and trained on the data collection tool from the World Health Organization/Health Action International (WHO/HAI) Workbook. Data was collected from public and private facilities in 12 states in the six geopolitical zones of Nigeria in April and May 2014. Returned survey forms were checked, entered and verified. Data analysis was carried out using the embedded analysis toolkit in the WHO/HAI Workbook after double-entry and auto-checking of data. Data was analysed for the public and private sectors.

RESULTS

Seven AMFm products are available in the country, and include AL (IPCA), Artemef (Cipla), Coartem AMFm (Novartis), Combisunate (Ajanta), Lumartem (Cipla) as well as Arsuamoon (Guilin) and Coarsucam (Sanofi-Winthrop). The results reveal that antimalarials are largely concentrated in the private sector (private pharmacies and PPMVs). About 86% of the surveyed facilities had at least one AMFm AL product whereas only 18% had any AMFm AA product. Results show that the availability of the various AMFm AL products varies across the country. Lumartem by Cipla has the highest national availability with 26.4%, closely followed by AL (IPCA) with 25.7%. Twenty seven (%) of the facilities had an RDT in stock.

CONCLUSION

The results obtained in this survey show that continuous monitoring of the antimalarial drug landscape is required to track progress in the fight against malaria in the country.

摘要

背景

疟疾是全球最重要的致死原因之一。对于有需求的人群而言,最有效治疗方法的使用仍不充分,且人们担心耐药性的出现。快速、准确且可及的疟原虫检测在许多疟疾流行地区促进更合理地使用日益昂贵的药物方面发挥着作用。快速诊断检测(RDTs)首次为所有高危人群提供了准确诊断的可能性,覆盖了那些无法获得高质量显微镜检测服务的人群。2010年,全球基金启动了疟疾可负担药品设施(AMFm),旨在增加优质青蒿素联合疗法(ACTs)用于疟疾治疗的可及性和使用率。AMFm涉及制造商价格谈判、补贴及其他干预措施。本研究的目的是记录通过AMFm融资战略在国家疟疾消除计划下提供的ACTs和RDTs的可得性。

材料与方法

从世界卫生组织/国际卫生行动(WHO/HAI)工作手册中系统挑选研究人员并就数据收集工具进行培训。2014年4月和5月从尼日利亚六个地缘政治区的12个州的公共和私立机构收集数据。对回收的调查问卷进行检查、录入和核实。在对数据进行双录入和自动检查后,使用WHO/HAI工作手册中嵌入的分析工具包进行数据分析。对公共部门和私营部门的数据进行了分析。

结果

该国现有七种AMFm产品,包括AL(IPCA公司)、Artemef(西普拉公司)、Coartem AMFm(诺华公司)、Combisunate(阿旃陀公司)、Lumartem(西普拉公司)以及Arsuamoon(桂林公司)和Coarsucam(赛诺菲 - 温思罗普公司)。结果显示,抗疟药主要集中在私营部门(私人药店和私营药品销售点)。约86%的被调查机构至少有一种AMFm的AL产品,而只有18%有任何AMFm的AA产品。结果表明,不同AMFm的AL产品在全国的可得性各不相同。西普拉公司的Lumartem在全国的可得性最高,为26.4%,紧随其后的是AL(IPCA公司),为25.7%。27%的机构有RDT库存。

结论

本次调查获得的结果表明,需要持续监测抗疟药情况,以跟踪该国抗击疟疾的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef84/11107871/bcebfce6ee29/MWJ-6-05-f1.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索