Department of General Practice, University of Turku, Turku, Finland.
Folkhälsan Research Center, Helsinki, Finland.
Sci Prog. 2024 Apr-Jun;107(2):368504241251649. doi: 10.1177/00368504241251649.
Ankle-brachial index (ABI) measurement is a widely used diagnostic test for lower extremity artery disease. Previously, a larger body surface area (BSA) has been associated with lower blood pressure and lower 2-h post-load glucose concentrations in the oral glucose tolerance test. Our aim was to evaluate whether BSA has an impact on ABI and the prevalence of lower ABI values.
ABI measurements were performed on 972 subjects aged 45 to 70 years at high cardiovascular disease (CVD) risk. Subjects with previously diagnosed kidney disease, CVD, and diabetes were excluded. Their BSA was calculated by the Mosteller formula. Study subjects were divided into five BSA levels corresponding to 12.5, 25, 25, 25, and 12.5 percentiles of the total distribution. Effect modification by BSA in ABI between sexes was derived from a four-knot restricted cubic splines regression model.
After adjustments for age, sex, pulse pressure, glucose regulation, waist circumference, alcohol intake, smoking status, leisure-time physical activity and medication, BSA level had a positive linear relationship with ABI ( for linearity <0.001). When BSA was less than 2.0 m, there was no difference between the sexes, but when BSA was higher than 2.0 m, men had higher ABI.
BSA shows a positive linear relationship with ABI in CVD risk subjects without manifested CVD. The difference in ABI between men and women is modified by BSA and is appreciable when BSA is larger than 2.0 m.
踝臂指数（ABI）测量是一种广泛用于下肢动脉疾病诊断的检测方法。此前，更大的体表面积（BSA）与较低的血压和口服葡萄糖耐量试验中 2 小时后负荷血糖浓度相关。我们的目的是评估 BSA 是否会影响 ABI 和较低 ABI 值的发生率。
在高心血管疾病（CVD）风险的 972 名 45 至 70 岁的受试者中进行 ABI 测量。排除了先前诊断为肾病、CVD 和糖尿病的患者。通过 Mosteller 公式计算他们的 BSA。研究对象分为五个 BSA 水平，对应于总分布的 12.5%、25%、25%、25%和 12.5%。通过四结限制三次样条回归模型得出 BSA 在性别间对 ABI 的影响修饰。
在校正年龄、性别、脉压、血糖调节、腰围、酒精摄入、吸烟状况、休闲时间体力活动和药物治疗后，BSA 水平与 ABI 呈正线性关系（线性检验<0.001）。当 BSA 小于 2.0 m 时，男女之间没有差异，但当 BSA 高于 2.0 m 时，男性的 ABI 更高。
在没有表现出 CVD 的 CVD 风险受试者中，BSA 与 ABI 呈正线性关系。BSA 可修饰男女之间 ABI 的差异，当 BSA 大于 2.0 m 时，差异明显。
