Departamento de Psicologia, Faculdade Filosofia e Ciencias Humanas, Universidade Federal de Minas Gerais.
Programa de Pos-graduacao em Neurociencias, Universidade Federal de Minas Gerais.
Neuropsychology. 2024 Jul;38(5):465-474. doi: 10.1037/neu0000957. Epub 2024 May 23.
Amyotrophic lateral sclerosis (ALS) is often shown to cause episodic memory deficits. Here, we investigated whether such memory deficits are differentially expressed according to the emotional valence of stimuli and whether they are similarly reproduced in both individuals with sporadic ALS (sALS) and familial Type 8 ALS (ALS8).
Twenty individuals with sALS, 18 individuals with ALS8, and 19 healthy controls were recruited for the study. After a neuropsychological and psychopathological assessment, all participants responded to a recognition memory test wherein images varying in terms of valence were initially shown. After a short interval, the images were shown again intermixed with new images, and the participants' task was to indicate whether each image was "old" or "new" and to estimate the confidence in their responses.
Both the sALS and the ALS8 groups showed significantly lower recognition of positive relative to negative valence images ( = 0.92 and = 0.74, respectively), an effect that was completely absent for healthy controls ( = 0.17). These effects were qualified by a significant interaction involving the factors of valence and group (η² = 0.12).
The current findings demonstrate that sALS and ALS8 are associated with decreased recognition of emotional information, an effect that is nonetheless restricted to positive valence stimuli. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
肌萎缩侧索硬化症（ALS）常表现出间歇性记忆缺陷。在这里，我们研究了这些记忆缺陷是否根据刺激的情绪效价而表现出不同，以及它们是否在散发性 ALS（sALS）个体和家族性 8 型 ALS（ALS8）个体中得到相似的重现。
共招募了 20 名 sALS 患者、18 名 ALS8 患者和 19 名健康对照者参加本研究。在进行神经心理学和精神病理学评估后，所有参与者均需完成一项识别记忆测试，在此测试中，根据效价的不同呈现图像。短暂间隔后，再次呈现图像，同时混入新图像，参与者的任务是判断每张图像是“旧”还是“新”，并对自己的反应进行信心评估。
sALS 和 ALS8 组对正性效价图像的识别显著低于负性效价图像（分别为 = 0.92 和 = 0.74），而健康对照组的这种效应完全不存在（ = 0.17）。这些效应受到涉及效价和组的因素的显著交互作用的限定（η² = 0.12）。
目前的研究结果表明，sALS 和 ALS8 与情绪信息识别减少有关，这种效应仅限于正性效价刺激。（PsycInfo 数据库记录（c）2024 APA，保留所有权利）。
