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Lactate levels in sepsis: don't forget the mitochondria.

作者信息

Nedel Wagner Luis, Portela Luis Valmor

机构信息

Laboratory of Neurotrauma and Biomarkers, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Intensive Care Unit, Grupo Hospitalar Conceição, Av. Francisco Trein, 596, Porto Alegre, RS, Brazil.

出版信息

Intensive Care Med. 2024 Jul;50(7):1202-1203. doi: 10.1007/s00134-024-07475-8. Epub 2024 May 23.

DOI:10.1007/s00134-024-07475-8
PMID:38780796
Abstract
摘要

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BMC Infect Dis. 2025 Sep 2;25(1):1095. doi: 10.1186/s12879-025-11527-9.
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Prognostic Value of the Lactate/Albumin Ratio for 28-Day Mortality in Pediatric Septic Shock: A Prospective Cohort Study.乳酸/白蛋白比值对小儿感染性休克28天死亡率的预后价值：一项前瞻性队列研究
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Dissecting the mediating role of inflammatory factors in the interaction between metabolites and sepsis: insights from bidirectional Mendelian randomization.

本文引用的文献

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Incidence of acute kidney injury and attributive mortality in acute respiratory distress syndrome randomized trials.急性呼吸窘迫综合征随机试验中急性肾损伤的发生率和归因死亡率。
Intensive Care Med. 2024 Aug;50(8):1240-1250. doi: 10.1007/s00134-024-07485-6. Epub 2024 Jun 12.
2
Effects of restrictive fluid therapy on the time to resolution of hyperlactatemia in ICU patients with septic shock. A secondary post hoc analysis of the CLASSIC randomized trial.限制液体疗法对 ICU 脓毒性休克患者乳酸清除时间的影响。CLASSIC 随机试验的事后二次分析。
Intensive Care Med. 2024 May;50(5):678-686. doi: 10.1007/s00134-024-07385-9. Epub 2024 Apr 10.
3
剖析代谢物与脓毒症相互作用中炎症因子的中介作用：来自双向孟德尔随机化的见解。
Front Endocrinol (Lausanne). 2024 Aug 14;15:1377755. doi: 10.3389/fendo.2024.1377755. eCollection 2024.
Association Between Hyperlactatemia, Perfusional Parameters, and Lymphocyte Mitochondrial Dysfunction in Septic Shock Patients.
脓毒症休克患者高乳酸血症、灌注参数与淋巴细胞线粒体功能障碍之间的关联
Shock. 2022 Mar 1;57(3):378-383. doi: 10.1097/SHK.0000000000001868.
4
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.拯救脓毒症运动：2021年脓毒症和脓毒性休克国际管理指南
Intensive Care Med. 2021 Nov;47(11):1181-1247. doi: 10.1007/s00134-021-06506-y. Epub 2021 Oct 2.
5
Lactate modulation of immune responses in inflammatory versus tumour microenvironments.在炎症和肿瘤微环境中，乳酸对免疫反应的调节作用。
Nat Rev Immunol. 2021 Mar;21(3):151-161. doi: 10.1038/s41577-020-0406-2. Epub 2020 Aug 24.